VEGF-C和CCR7的表达与鼻咽癌淋巴结转移的关系

发布时间：2019-04-25 23:56

【摘要】：目的探讨趋化因子受体7(CCR7)和血管内皮生长因子-C(VEGF-C)在鼻咽癌组织中的表达及其与患者临床病理特征的关系。方法应用免疫组化En Vision两步法检测15例正常鼻咽黏膜组织及69例鼻咽癌组织中CCR7和VEGF-C的表达水平,分析其表达水平与鼻咽癌患者临床病理特征的关系。结果 CCR7及VEGF-C在鼻咽癌组织中呈高表达分别占39例(56.52%)、25例(36.23%),而在15例正常鼻咽黏膜组织中均呈低表达(P0.05)。CCR7和VEGF-C表达与肿瘤淋巴结转移有关(P0.05),与肿瘤临床分期、浸润深度、是否远处转移、患者年龄及性别等均无关(P0.05);CCR7和VEGF-C蛋白表达呈显著相关性(r=0.366,P=0.002)。结论 CCR7和VEGF-C蛋白高表达与鼻咽癌淋巴结转移密切相关,可能促进淋巴管新生和癌细胞迁移等过程。
[Abstract]:Aim to investigate the expression of chemokine receptor 7 (CCR7) and vascular endothelial growth factor-C (VEGF-C) in nasopharyngeal carcinoma (NPC) and their relationship with clinicopathological features. Methods the expression of CCR7 and VEGF-C in 15 cases of normal nasopharyngeal mucosa and 69 cases of nasopharyngeal carcinoma (NPC) were detected by immunohistochemical En Vision two-step method, and the relationship between the expression level and clinicopathological features of NPC was analyzed. Results the high expression of CCR7 and VEGF-C were found in 39 cases (56.52%) and 25 cases (36.23%) of NPC, respectively. The expression of CCR7 and VEGF-C were correlated with lymph node metastasis (P0.05), clinical stage, depth of invasion and distant metastasis, and the expression of CCR7 and CCR7 were related to lymph node metastasis (P0.05), and the expression of CCR7 and CCR7 were correlated with tumor stage, depth of invasion and distant metastasis. There was no significant difference in age and sex (P0.05). There was a significant correlation between the expression of CCR7 and VEGF-C (r = 0.366, P = 0.002). Conclusion the high expression of CCR7 and VEGF-C protein is closely related to lymph node metastasis of nasopharyngeal carcinoma, which may promote lymphangiogenesis and migration of cancer cells.
【作者单位】：广西壮族自治区南溪山医院肿瘤科;
【基金】：广西壮族自治区卫生厅科研项目(编号:Z2013292)
【分类号】：R739.63

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