鼓室注射地塞米松对老年分泌性中耳炎鼓膜穿刺术患者实验室指标及听力恢复的影响

发布时间：2019-05-14 19:03

【摘要】：目的探讨鼓室注射地塞米松对老年分泌性中耳炎(SOM)激素骨膜穿刺术患者血清炎性因子、免疫功能及听力恢复的影响。方法老年SOM患者146例,采用随机数字表法分为观察组和对照组各73例。对照组采取鼓膜穿刺术治疗,观察组采取鼓膜穿刺术联合鼓室注射糖皮质激素治疗,比较两组血清炎性因子、免疫功能、听觉阈值、临床疗效。结果治疗1个月后,观察组有效率明显高于对照组(χ~2=10.860,P0.01);血清内皮素(ET)-1、肿瘤坏死因子(TNF)-α、γ-干扰素(INF-γ)含量明显低于对照组(P0.05);T淋巴细胞亚群CD3~+、CD4~+、CD4~+/CD8~+均明显高于对照组(P0.05);500、1 000、2 000 Hz等听阈值明显低于对照组(P0.001)。结论鼓室注射地塞米松有助于缓解老年SOM彭膜穿刺术患者血清炎性因子表达水平,改善免疫功能,提高听力水平。
[Abstract]:Objective to investigate the effect of tympanic injection of dexamethasone on serum inflammatory factors, immune function and hearing recovery in elderly patients with secretory otitis media treated with (SOM) hormone periosteum puncture. Methods 146 elderly patients with SOM were randomly divided into observation group (n = 73) and control group (n = 73). The control group was treated with tympanic membrane puncture, and the observation group was treated with tympanic membrane puncture combined with tympanic injection of glucocorticoid. The serum inflammatory factors, immune function, auditory threshold and clinical efficacy were compared between the two groups. Results after one month of treatment, the effective rate in the observation group was significantly higher than that in the control group (蠂 ~ 2 鈮，

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