组织粘合剂联合羊膜移植在角膜溃疡中的应用研究

发布时间：2019-05-28 10:55

【摘要】：目的观察与探讨氰基丙烯酸组织粘合剂联合羊膜移植在角膜溃疡中的临床疗效。方法采用前瞻性临床对照研究,将58例接受角膜溃疡羊膜移植术的患者随机分为两组:粘合组33例,用组织粘合剂粘贴羊膜;缝线组25例,用10-0尼龙线缝合羊膜。比较两组手术时间和术后症状,随访6~12个月,观察局部反应、角膜上皮生长情况及羊膜贴附情况等。结果组织粘合剂组平均手术时间(13.31±2.81)min,比缝线组(18.72±4.33)min明显缩短(P0.05)。组织粘合剂组术后症状较缝线组轻,羊膜植片较缝线组贴合紧密,其余两组差异无统计学意义。结论角膜溃疡羊膜移植术中使用氰基丙烯酸组织粘合剂粘合羊膜安全、简便,可代替传统的缝线缝合并在一定程度上优于缝线,值得在临床上进一步研究及推广。
[Abstract]:Objective to observe and investigate the clinical effect of cyanoacrylic acid tissue adhesive combined with amniotic membrane transplantation in corneal ulcer. Methods 58 patients undergoing amniotic membrane transplantation with corneal ulcer were randomly divided into two groups: adhesive group (n = 33) and suture group (n = 25). The operation time and postoperative symptoms were compared between the two groups. The local reaction, corneal epithelial growth and amniotic membrane adhesion were observed. Results the average operation time of tissue adhesive group was (13.31 卤2.81) min, which was significantly shorter than that of suture group (18.72 卤4.33) min (P 0.05). The postoperative symptoms in the tissue adhesive group were lighter than those in the suture group, and the amniotic membrane graft was more closely fitted than that in the suture group, but there was no significant difference between the other two groups. Conclusion it is safe and simple to use cyanoacrylic acid tissue adhesive to glue amniotic membrane in amniotic membrane transplantation of corneal ulcer. It can replace the traditional suture and is superior to suture to a certain extent. It is worth further study and popularize in clinic.
【作者单位】：南昌大学第一附属医院眼科;
【基金】：国家自然科学基金(No:81160118、81400372) 江西省科技支撑计划项目(No:20161BBG70164) 江西省教育厅科技计划项目(No:GJJ150242) 江西省卫计委科技计划项目(No:20155131)
【分类号】：R779.6

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