头孢呋辛钠对白内障患者术后眼内感染的预防控制效果分析

发布时间：2019-06-19 17:55

【摘要】：目的探讨头孢呋辛钠对白内障患者术后眼内感染的预防控制效果,为临床用药提供指导。方法选取2010年5月-2013年4月在医院眼科手术治疗的54例白内障患者为对照组,按照常规治疗预防感染,另选取2013年5月-2016年4月医院眼科手术治疗的55例白内障患者为观察组,在对照组的基础上术后前房注射头孢呋辛钠,比较两组患者术后2周视力、不良反应(眼角膜水肿、前房积血、前房纤维素反应)、术后眼内感染和病原菌分布。结果观察组患者术后视力较对照组明显提高,差异有统计学意义(P0.01);观察组患者术后总的不良反应率为1.82%,对照组为9.26%,观察组不良反应率明显低于对照组患者,差异有统计学意义(P0.01);观察组患者术后未发生眼内感染,对照组患者发生眼内感染2例,感染率为3.70%,观察组患者眼内感染率明显低于对照组患者,差异有统计学意义(P0.01);对照组感染患者中共分离出病原菌3株,其中革兰阴性菌1株为铜绿假单胞菌,革兰阳性菌2株为表皮葡萄球菌、金黄色葡萄球菌,观察组患者病原菌分布与对照组患者比较,差异均无统计学意义。结论前房注射头孢呋辛钠可减少患者术后不良反应,减少眼内感染率,可作为白内障患者术后眼内感染预防控制措施。
[Abstract]:Objective to investigate the preventive and control effect of cefuroxime sodium on intraocular infection in patients with cataract after operation, and to provide guidance for clinical use of cefuroxime sodium. Methods 54 cataract patients treated by ophthalmic surgery in hospital from May 2010 to April 2013 were selected as control group, and 55 cataract patients treated by ophthalmic surgery in hospital from May 2013 to April 2016 were selected as observation group. Cefuroxime sodium was injected into the anterior chamber on the basis of control group. The visual acuity and adverse reactions (corneal edema, hyphema in anterior chamber) were compared between the two groups. Anterior chamber cellulose reaction), postoperative intraocular infection and pathogen distribution. Results the postoperative visual acuity of the observation group was significantly higher than that of the control group (P 0.01), the total adverse reaction rate of the observation group was 1.82%, that of the control group was 9.26%, and the adverse reaction rate of the observation group was significantly lower than that of the control group (P 0.01). There was no intraocular infection in the observation group and 2 cases in the control group, the infection rate was 3.70%. The intraocular infection rate in the observation group was significantly lower than that in the control group (P 0.01). Three strains of pathogenic bacteria were isolated from the patients with infection in the control group, including 1 strain of Pseudomonas aeruginosa and 2 strains of Staphylococcus epidermidis and Staphylococcus aureus. There was no significant difference in the distribution of pathogenic bacteria between the observation group and the control group. Conclusion the injection of cefuroxime sodium into the anterior chamber can reduce the postoperative adverse reactions and intraocular infection rate, which can be used as a preventive and control measure for cataract patients.
【作者单位】：湖州市中心医院眼科;
【基金】：吴阶平医学基金资助项目(20156544)
【分类号】：R779.66

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