玻璃酸钠联合0.1%氟米龙治疗干眼症的临床观察

发布时间：2019-06-21 03:38

【摘要】：目的:观察玻璃酸钠滴眼液联合0.1%氟米龙滴眼液治疗中重度干眼症的疗效及安全性。方法:选择确诊的中重度干眼症患者96例(198眼),按随机数字表法分为观察组和对照组,各48例(96眼)。对照组采用玻璃酸钠滴眼液0.04 ml,tid;观察组患者在对照组基础上加用0.1%氟米龙滴眼液0.04 ml,tid,两组均治疗4周。观察两组患者治疗前后眼部症状评分、角膜荧光染色试验、泪膜破裂时间、泪液分泌情况试验、临床疗效及不良反应。结果:治疗后2、4周观察组患者眼部症状评分、角膜荧光素染色、泪膜破裂时间较治疗前显著改善,且显著优于对照组,差异有统计学意义(P0.05);两组患者治疗前后泪液分泌试验结果比较,差异无统计学意义(P0.05);治疗后,观察组患者总有效率(97.92%)显著高于对照组(86.46%),差异有统计学意义(P0.05);两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:玻璃酸钠滴眼液联合0.1%氟米龙滴眼液能提高中重度干眼症患者的临床疗效,且安全性较好。
[Abstract]:Objective: to observe the efficacy and safety of sodium hyaluronate eye drops combined with 0.1% flunomide eye drops in the treatment of moderate and severe xerophthalmia. Methods: 96 patients (198 eyes) with moderate and severe xerophthalmia were randomly divided into observation group (48 cases, 96 eyes) and control group (48 cases, 96 eyes). The patients in the control group were treated with sodium hyaluronate 0. 04 ml,tid; eye drops on the basis of the control group and 0. 4% flunomide eye drops were treated with 0. 04 ml,tid, eye drops for 4 weeks. The scores of ocular symptoms, corneal fluorescence staining test, tear film rupture time, tear secretion test, clinical efficacy and adverse reactions were observed before and after treatment. Results: at 2 and 4 weeks after treatment, the scores of eye symptoms, corneal fluorescein staining and tear film rupture time in the observation group were significantly better than those in the control group, and the difference was statistically significant (P 0.05). There was no significant difference in tear secretion test between the two groups before and after treatment (P 0.05). After treatment, the total effective rate of the patients in the observation group (97.92%) was significantly higher than that in the control group (86.46%), the difference was statistically significant (P 0.05), but there was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: sodium hyaluronate eye drops combined with 0.1% flunomide eye drops can improve the clinical efficacy and safety of moderate to severe dry eye patients.
【作者单位】：火箭军总医院清河门诊部;
【分类号】：R777.34

【相似文献】