他氟前列素与拉坦前列素治疗慢性开角型青光眼疗效相当
发布时间：2019-06-21 04:05
【摘要】：为了对他氟前列素用于开角型青光眼治疗提供实验依据,本研究对比观察抗青光眼新药他氟前列素和常用药物拉坦前列素治疗慢性开角型青光眼的疗效。我们选取2014年08月至2015年12月我院收治的120例原发性慢性开角型青光眼患者,按随机数字表法分为他氟前列素组(0.001 5%,1次/d,1滴/次)和拉坦前列素组(0.005%,1次/d,1滴/次),对比观察两组患者的眼压、视野缺损、角膜中央厚度、前房深度和视网膜中央动脉血流动力学指标。研究结果如下:(1)治疗后两组的眼压和视野缺损度显著降低(p0.05),且拉坦前列素组的视野缺损改善更为显著(p0.05);(2)治疗后两组的角膜中央厚度显著降低(p0.05),但两组的前房深度与治疗前比较无差异(p0.05);(3)治疗后两组的PSV、EDV升高而RI降低(p0.05)。以上结果提示,新药他氟前列素对青光眼患者的治疗效果与临床常用药物拉坦前列素相当,同时在改善患者的视野缺损度方面优于拉坦前列素,且安全性好,值得临床推广使用。
[Abstract]:In order to provide experimental basis for the treatment of open-angle glaucoma with tafluoroprostol, the efficacy of tafluoroprostol, a new anti-glaucoma drug, and latanoprost, a common drug, in the treatment of chronic open-angle glaucoma was compared and observed in this study. From August 2014 to December 2015, 120 patients with primary chronic open-angle glaucoma were randomly divided into tafluproprostol group (0.001, once a day, 1 drop / time) and latanoprostol group (0.005%, once a day, 1 drop / time). The intraocular pressure (IOP), visual field defect and central corneal thickness were compared between the two groups. Anterior chamber depth and hemodynamic parameters of central retinal artery. The results were as follows: (1) the intraocular pressure (IOP) and visual field defect (p0.05) were significantly decreased in the two groups after treatment (p0.05), and the visual field defect in the Latanprostol group was significantly improved (p0.05); (2). After treatment, the central corneal thickness in the two groups decreased significantly (p0.05), but the depth of the anterior chamber in the two groups was not different from that before treatment (p0.05); (3). After treatment, the PSV,EDV and RI in the two groups increased and RI decreased (p0.05). The above results suggest that the therapeutic effect of tafluoroprostol on glaucoma patients is similar to that of latan prostol, and it is better than Ratanprostol in improving the degree of visual field defect, and it is worth popularizing and using in clinic.
【作者单位】： 齐齐哈尔市医学院附属第三医院眼科;
【基金】：齐齐哈尔市医学院附属第三医院
【分类号】：R775.2
[Abstract]:In order to provide experimental basis for the treatment of open-angle glaucoma with tafluoroprostol, the efficacy of tafluoroprostol, a new anti-glaucoma drug, and latanoprost, a common drug, in the treatment of chronic open-angle glaucoma was compared and observed in this study. From August 2014 to December 2015, 120 patients with primary chronic open-angle glaucoma were randomly divided into tafluproprostol group (0.001, once a day, 1 drop / time) and latanoprostol group (0.005%, once a day, 1 drop / time). The intraocular pressure (IOP), visual field defect and central corneal thickness were compared between the two groups. Anterior chamber depth and hemodynamic parameters of central retinal artery. The results were as follows: (1) the intraocular pressure (IOP) and visual field defect (p0.05) were significantly decreased in the two groups after treatment (p0.05), and the visual field defect in the Latanprostol group was significantly improved (p0.05); (2). After treatment, the central corneal thickness in the two groups decreased significantly (p0.05), but the depth of the anterior chamber in the two groups was not different from that before treatment (p0.05); (3). After treatment, the PSV,EDV and RI in the two groups increased and RI decreased (p0.05). The above results suggest that the therapeutic effect of tafluoroprostol on glaucoma patients is similar to that of latan prostol, and it is better than Ratanprostol in improving the degree of visual field defect, and it is worth popularizing and using in clinic.
【作者单位】： 齐齐哈尔市医学院附属第三医院眼科;
【基金】：齐齐哈尔市医学院附属第三医院
【分类号】：R775.2
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