声脉冲辐射成像技术在早期非酒精性脂肪性肝炎诊断中的应用价值

发布时间：2018-03-27 18:54

本文选题：非酒精性脂肪性肝炎　切入点：声脉冲辐射力成像技术　出处：《中国医学科学院学报》2017年03期

【摘要】：目的评估声脉冲辐射成像技术(ARFI)在早期非酒精性脂肪性肝炎(NASH)诊断中的应用价值。方法采用随机数字表法将32只SD大鼠随机分为普通饲料组(n=8)和高脂饲料组(n=24),分别于4、8、12、16周末从高脂饲料组及普通饲料组随机抽取6只及2只行体质量、血生化、常规超声及ARFI检测,处死后取大鼠肝脏行HE染色,观察病理。结果 32只大鼠均未出现肝纤维化,根据病理结果分为M1组[轻中度单纯性脂肪肝(SS)]、M2组(重度SS)、M3组(重度SS合并早期NASH)和C组(正常对照)4组,早期NASH仅出现在重度脂肪肝组,其分布差异有统计学意义(P=0.006)。常规超声诊断脂肪肝程度与病理检查结果的符合率为34.4%(11/32)。M3组的ARFI值为(1.16±0.04)m/s,明显低于M2组的(1.22±0.05)m/s(t=2.301,P=0.04);M3组的LDL-C为(1.53±0.07)mmol/L,明显高于M2组的(1.21±0.22)mmol/L(t=3.075,P=0.01);两组大鼠在三酰甘油、总胆固醇、高密度脂蛋白、谷草转氨酶、谷丙转氨酶和体质量方面差异均无统计学意义(P均0.05)。结论早期NASH的出现与脂肪肝程度相关。ARFI值可为重度SS患者是否合并早期NASH提供重要信息。
[Abstract]:Objective to evaluate the value of acoustic pulse radiography (ARFI) in the diagnosis of early non-alcoholic fatty hepatitis (NASH). Methods 32 SD rats were randomly divided into normal diet group (n = 32) and high-fat diet group (n = 24). At the end of the week, 6 and 2 rats were randomly selected from the high fat diet group and the general feed group. Blood biochemistry, routine ultrasound and ARFI were detected. The liver of the rats were sacrificed for HE staining and pathological observation. Results there was no hepatic fibrosis in 32 rats. According to the pathological results, they were divided into M1 group (mild to moderate simple fatty liver) and M 2 group (severe SS with early stage NASH) and C group (normal control group 4). Early NASH only appeared in severe fatty liver group. The distribution difference was statistically significant (P < 0.006). The coincidence rate between the degree of fatty liver diagnosed by conventional ultrasound and pathological examination was 1.16 卤0.04 渭 m / s in 34.4%(11/32).M3 group, which was significantly lower than that in M2 group (1.22 卤0.05 m / s / s), and the LDL-C in group M3 was 1.53 卤0.07 mmol / L, which was significantly higher than that in M _ 2 group (1.21 卤0.22 mmol / L ~ (3.075) P ~ (-1)). Total cholesterol, high density lipoprotein, glutamic oxaloacetic transaminase, There was no significant difference in glutamate-pyruvic transaminase and body mass (P < 0.05). Conclusion the occurrence of early NASH is related to the degree of fatty liver. ARFI may provide important information for the patients with severe SS complicated with early NASH.
【作者单位】：中国医学科学院北京协和医学院北京协和医院超声医学科;
【基金】：中国医学科学院北京协和医学院研究生创新基金(2014-10023-1002-3008)~~
【分类号】：R445.1;R575

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