益生菌治疗肠易激综合征疗效的Meta分析

发布时间：2018-04-20 18:42

本文选题：肠易激综合征 + 有益菌种　；参考：《新疆医科大学》2014年硕士论文

【摘要】：目的：探讨益生菌治疗肠易激综合征(IBS)的临床疗效及安全性。方法：计算机检索PubMed.国际Cochrane中心、Embase.中国生物医学文献数据库、相关期刊论文、万方数据库、维普数据库,收集益生菌治疗IBS的随机对照试验(RCT),并手工检索已获文献的参考文献,由两位评价者按照纳入和排除标准筛选、提取资料并行方法学质量评价,采用RevMan5.0软件对数据行Meta分析。结果：共纳入19个RCT,2172例患者,Meta分析结果显示：益生菌较安慰剂在改善患者总体症状积分[SMD=-0.18,95%CI(-0.28,-0.08),P=0.0006]、腹痛[SMD=-0.13,95%CI(-0.21,-0.04),P=0.003]、腹胀[SMD=-0.15,95%CI(-0.25,-0.05), P=0.004]、排便不适感[SMD=-0.15,95%CI(0.27,-0.02),P=0.02]方面均有显著意义,在总体生活质量[SMD=0.09,95%CI(-0.08,0.25),P=0.30]、不良反应发生率[RR=0.91,95%CI(0.71,1.16),P=0.45]方面无显著意义。结论：目前证据显示益生菌制剂能有效改善IBS患者的临床症状,且安全性好,但现有RCT在力法质量学以及研究设计上存在一定不足,今后的研究应在菌株、剂量、疗程、IBS亚组患者方面进行严谨、高质量、大样本长期随访的临床研究予以证实。
[Abstract]:Objective: to investigate the clinical efficacy and safety of probiotics in the treatment of irritable bowel syndrome (IBS). Methods: PubMed. was searched by computer. International Cochrane Center. Chinese Biomedical Literature Database, full text Database of Chinese Journals, Wanfang Database, Wipu Database, Random controlled trial of probiotic treatment of IBS, and manual retrieval of references obtained, According to the inclusion and exclusion criteria, two evaluators were selected to extract the data and evaluate the quality of parallel methodology. The RevMan5.0 software was used to analyze the data row Meta. There was no significant difference in the overall quality of life (SMD-0.09 / 95) and the incidence of adverse reactions (RRR0.91 / 95CI0.71 / 1.16 / P0.45), and there was no significant difference in the overall quality of life (SMD-0.08) and 0.25% (P = 0.30), and there was no significant difference in the incidence of adverse reactions. Conclusion: the current evidence shows that probiotics can effectively improve the clinical symptoms of patients with IBS, and the safety is good, but there are some deficiencies in the quality of force method and the research and design of the existing RCT, the future research should be in the strain, dosage. A rigorous, high-quality, long-term follow-up study was conducted in the IBS subgroup.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R574.4

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