乙型肝炎肝硬化并发原发性肝癌患者感染的临床特征

发布时间：2018-05-04 13:40

本文选题：乙型肝炎 + 肝硬化　；参考：《中华医院感染学杂志》2016年14期

【摘要】：目的对乙型肝炎病毒感染后出现肝硬化并发原发性肝癌的患者感染情况进行分析,为临床做出早期诊断及预防治疗提供理论依据。方法对2013年5月-2015年5月诊治374例乙型肝炎病毒感染肝硬化并发原发性肝癌的患者的临床资料进行分析,将其列为A组;并选择同期内636例受到乙型肝炎病毒感染的肝硬化患者进行对比分析,将其列为B组;对所选患者运用荧光聚合酶链反应实施乙型肝炎病毒载量检测,运用酶联免疫吸附法进行乙型肝炎病毒五项指标检测,肝功能运用全自动生化仪器进行检测,对两组患者的临床特征进行综合分析。结果 HBV DNA(log10IU/mL)在A组平均值为(5.47±1.35),B组平均值为(5.47±1.35)。A组与B组HBV DNA阳性率比较差异有统计学意义(P0.05);两组患者的胆汁酸(TBA)、谷丙转氨酶(ALT)、总胆红素(TB)、谷胺酰转肽酶(GGT)、球蛋白(GLB)、甲胎蛋白(AFP)以及碱性磷酸酶(ALP)比较差异有统计学意义(P0.05)。结论对于乙型肝炎肝硬化患者来说,年龄40岁,男性,而且HBeAb呈阳性,HBV DNA低水平复制时应早期对原发性肝癌进行排查,在此基础上还需要联合检测ALP、GGT、AFP三项指标,这样能够才能够进行早期诊断和预防治疗。
[Abstract]:Objective to analyze the infection of patients with liver cirrhosis complicated with primary liver cancer after hepatitis B virus infection, and to provide theoretical basis for early diagnosis and prevention and treatment of hepatitis B virus infection. Methods the clinical data of 374 patients with hepatitis B virus infection complicated with primary liver cancer from May 2013 to May 2015 were analyzed and classified as group A. During the same period, 636 patients with liver cirrhosis infected by hepatitis B were compared and classified as group B. the selected patients were tested for hepatitis B virus load by fluorescence polymerase chain reaction (FPCR). The five indexes of hepatitis B virus were detected by enzyme linked immunosorbent assay (Elisa) and the liver function was detected by automatic biochemical apparatus. The clinical characteristics of the two groups were analyzed comprehensively. Results the average value of HBV DNA log10 IUP / mL in group A was 5.47 卤1.35. The average value of HBV DNA in group B was 5.47 卤1.35. The positive rate of HBV DNA in group A was significantly higher than that in group B (P 0.05), and the positive rates of bile acid in group A and B were significantly higher than those in group B (P < 0.05), and the levels of bile acid, alanine aminotransferase (alt), total bilirubin (TBT), glutamyl transpeptidase (GGTN), globulin (GLB) were significantly higher in group A than those in group B (P < 0.05). The difference of AFP and ALP between AFP and ALP was statistically significant (P 0.05). Conclusion for patients with hepatitis B cirrhosis, the age of 40 years old, male, and HBeAb positive HBV DNA low level replication should be carried out early primary liver cancer screening, on the basis of this, we also need to jointly detect three indicators of ALP GGT AFP. This allows for early diagnosis and preventive treatment.
【作者单位】：河北大学附属医院介入血管外科;河北大学附属医院肾内科;
【基金】：河北省卫生厅科研基金项目(20130295)
【分类号】：R512.62;R575.2;R735.7

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