肝硬化患者生存质量与相关因素的研究

发布时间：2018-06-20 17:56

本文选题：肝硬化 + 生存质量　；参考：《山西医科大学》2014年硕士论文

【摘要】：研究目的：本研究的目的是了解由三种不同原因所导致的肝硬化患者生存质量的状况和差异,并就可能影响其生存质量的主要因素进行探讨,了解患者的需求和需要帮助的程度,为肝硬化患者改善和提高其生存质量给予相应的理论基础的提供。研究方法：采用方便抽样原则,应用简明生命质量测量量表(SF-36)中文版对试验组肝硬化患者120例[根据病因不同分为肝炎肝硬化(60例)、酒精性肝硬化(30例)、原发性胆汁性肝硬化(30例)3组]和对照组健康人群(30例)进行调查。比较各组间生存质量总分及8个维度(躯体健康、躯体角色功能、躯体疼痛、总体健康感受、精力、社会功能、情绪角色功能和心理健康)的得分,进一步探讨肝硬化患者生存质量的状况。同时收集各研究对象组的一般特征,试验组同时收集可能与肝硬化患者生存质量相关的因素,包括疾病相关因素和非疾病相关因素两部分内容,应用SPSS10.0统计软件包进行数据处理,采用相关统计描述,并采用秩和检验、方差分析和多元回归等统计方法进行分析,研究与肝硬化患者生存质量相关的主要因素。研究结果： 1.三组不同病因的肝硬化患者的生存质量与正常人群相比均有不同程度降低。在总体生存质量及除躯体疼痛外的7个维度上肝硬化患者组均比正常对照组降低。3组不同病因的肝硬化患者的生存质量进行组间比较,酒精性硬肝化患者组在生存质量总分及躯体角色功能、社会功能、情绪角色功能、心理健康4个维度上均比肝炎肝硬化患者组和原发性胆汁性肝硬化降低,而肝炎肝硬化患者组和原发性胆汁性肝硬化患者组相比,则在情绪角色功能1个维度降低。 2.在其他条件相同的情况下,患者的肝硬化Child-pugh分级、发病时间、自觉不适症状与患者的生存质量呈负相关；患者的社会支持程度越高,医保状况越完善、焦虑、抑郁程度越低,年龄越大,患者的生存质量就越高,除酒精性肝硬化的患者外,男性较女性的生存质量高。而患者的家庭人均收入、教育水平、营养状况则与生存质量无明显相关性。结论肝硬化患者的生存质量明显下降,包括年龄、病程、Child-pugh分级、不适症状、焦虑与抑郁程度、性别、医疗费用支付方式、社会支持在内的诸多因素皆影响肝硬化患者的生存质量。
[Abstract]:Objective: the purpose of this study was to understand the status and difference of quality of life in patients with cirrhosis caused by three different causes, and to explore the main factors that may affect their quality of life. To understand the needs of patients and the degree of need for help to provide a theoretical basis for improving and improving the quality of life of patients with liver cirrhosis. Research methods: using the principle of convenient sampling, A brief quality of life scale (SF-36) was used in 120 patients with liver cirrhosis in the trial group (60 cases of hepatitis cirrhosis, 30 cases of alcoholic cirrhosis and 30 cases of primary biliary cirrhosis) according to their etiology. Group A (30 cases of healthy population) were investigated. The scores of total scores of quality of life and 8 dimensions (physical health, physical role function, physical pain, overall health feeling, energy, social function, emotional role function and mental health) were compared between the groups. To further investigate the quality of life in patients with cirrhosis. At the same time, the general characteristics of the study groups were collected, and the factors that might be related to the quality of life of patients with liver cirrhosis, including disease-related factors and non-disease-related factors, were collected simultaneously in the trial group. The data were processed by SPSS 10.0 software package, and the correlation statistical description was used. The main factors related to the quality of life of patients with liver cirrhosis were analyzed by rank sum test, variance analysis and multivariate regression. Results: 1. The quality of life of three groups of cirrhosis patients with different etiology was lower than that of normal people. The overall quality of life (QOL) and the quality of life (QOL) of cirrhotic patients with different etiology were lower than those of the normal control group in 7 dimensions except somatic pain. The total quality of life (QOL) scores, somatic role function, social function, emotional role function and mental health in alcoholic group were lower than those in patients with hepatitis cirrhosis and primary biliary cirrhosis. Compared with patients with primary biliary cirrhosis, there was a decrease of 1 dimension of emotional role function in patients with hepatitis and cirrhosis. 2. 2. Under the same conditions, Child-pugh grade, onset time, symptoms of discomfort were negatively correlated with the patients' quality of life; the higher the social support, the better the health insurance, the lower the anxiety, the lower the depression. The older the patient, the higher the quality of life, with the exception of alcoholic cirrhosis, higher quality of life for men than for women. There was no significant correlation between family income, education, nutrition and quality of life. Conclusion the quality of life of patients with liver cirrhosis decreased significantly, including age, course of disease, Child-pugh grade, symptoms of discomfort, anxiety and depression, sex, and the way of paying for medical expenses. Many factors, including social support, affect the quality of life of patients with liver cirrhosis.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R575.2

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