粪便钙卫蛋白与溃疡性结肠炎肠道病变程度及范围的相关性

发布时间：2018-08-16 07:41

【摘要】：目的探讨钙卫蛋白(FC)水平与溃疡性结肠炎(UC)肠道病变严重程度、病变范围之间的关系。方法 UC患者纳入后行结肠镜检查、抽血及留取粪便标本检测钙卫蛋白。参照UC内镜严重程度指数(UCEIS)对5个结肠肠段进行内镜评分,为评价FC水平与病变严重程度、病变范围之间的关系,应用Spearman相关性分析FC与最高内镜评分(M-UCEIS)、总内镜评分(S-UCEIS)之间关系。结果共有64例UC完成82次结肠镜检查及FC检测。FC水平与M-UCEIS明显相关(r=0.794,P0.01)。应用ROC曲线分析,鉴别内镜病变中重度的最佳界值510.6 mg/kg,敏感度和特异度分别为71.4%和100.0%。与M-UCEIS相比,FC水平与S-UCEIS强相关(r=0.821,P0.01)。结论 FC水平与UC肠道黏膜病变范围、病变严重程度相关,可作为结肠镜的非侵入性替代方法。
[Abstract]:Objective to investigate the relationship between the level of calcitonin (FC) and the severity and extent of (UC) intestinal lesions in ulcerative colitis. Methods the patients with UC were examined by colonoscopy, blood samples and fecal samples were collected for calcitonin. According to UC endoscopic severity index (UCEIS), five colon segments were evaluated by endoscopy to evaluate the relationship between FC level and severity and extent of lesion. The relationship between FC and maximum Endoscopic score (M-UCEIS) and Total Endoscopic score (S-UCEIS) was analyzed by Spearman correlation analysis. Results A total of 64 patients with UC underwent 82 colonoscopy and FC examination. The level of FC was significantly correlated with M-UCEIS (r = 0.794, P 0.01). By ROC curve analysis, the optimal threshold value of 510.6 mg / kg was obtained for the differential diagnosis of moderate and severe endoscopic lesions. The sensitivity and specificity were 71.4% and 100.0%, respectively. Compared with M-UCEIS, FC level was strongly correlated with S-UCEIS (r = 0.821, P 0.01). Conclusion FC level is correlated with the extent and severity of UC intestinal mucosal lesions, and can be used as a noninvasive alternative to colonoscopy.
【作者单位】：深圳市南山区人民医院消化内科;深圳市南山区人民医院中心实验室;
【基金】：深圳市南山区科技创新局资助项目(编号:南科研卫2013020号)
【分类号】：R574.62

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