非酒精性脂肪肝病中长链非编码RNA的表达谱

发布时间：2018-10-21 13:49

【摘要】：目的:分析非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)中长链非编码RNA(lncRNA)的表达谱特征。方法:采用lncRNA-m RNA基因芯片检测单纯性胆囊结石伴或不伴NAFLD患者的肝组织样本,获得lncRNA差异性表达谱。进一步使用生物信息学技术对差异表达的基因予以分析。结果:与正常样本相比,NAFLD肝样本内共有1 735个lncRNAs和1 485个mRNAs异常表达,其中535个lncRNAs和760个mRNAs上调,1 200个lncRNAs和725个mRNAs下调。结论:与正常肝组织相比,NAFLD组织中lncRNA表达谱明显异常,这些lncRNAs可能在NAFLD的发生和发展中发挥重要作用。
[Abstract]:Objective: to analyze the characteristics of long chain non-coding RNA (lncRNA) expression in non-alcoholic fatty liver disease (non-alcoholic fatty liver disease,NAFLD). Methods: lncRNA-m RNA gene chip was used to detect the liver tissue samples of patients with or without NAFLD in simple gallstone, and the differential expression profile of lncRNA was obtained. Further use of bioinformatics to analyze differentially expressed genes. Results: there were 1 735 lncRNAs and 1 485 mRNAs abnormal expression in NAFLD liver samples, 535 lncRNAs and 760 mRNAs up-regulated, 1 200 lncRNAs and 725 mRNAs down-regulated. Conclusion: compared with normal liver tissues, lncRNA expression profiles in NAFLD tissues are significantly abnormal, and these lncRNAs may play an important role in the occurrence and development of NAFLD.
【作者单位】： 中南大学湘雅三医院急诊科;中南大学湘雅三医院肝胆外科;中南大学湘雅三医院康复科;
【基金】：国家自然科学基金(81600461)~~
【分类号】：R575.5

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