新疆地区维吾尔族非酒精性脂肪肝患者血清脂联素水平及与肝脏酶学指标、血脂的相关性

发布时间：2018-11-18 19:55

【摘要】：目的探讨新疆地区维吾尔族成人非酒精性脂肪肝(NAFLD)患者血清脂联素(APN)水平的变化特点及与肝脏酶学指标、血脂、尿酸等指标的相关性。方法选取558名健康体检者,根据B超结果分为NAFLD组289例与健康照组(非NAFLD组,269例),详细测量并记录两组年龄、身高、体重、体质指数(BMI)、腹围(WC)、腰高比(WHtR)、收缩压(SBP)、舒张压(DBP),测定肝脏酶学指标、空腹血糖(FPG)、血脂、尿酸(UA),同时应用酶联免疫吸附法测定血清中APN等指标。采用非条件Logistic回归分析NAFLD发生的危险因素。结果 NAFLD患者BMI、WHtR、SBP、DBP、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、谷草转氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、FPG、UA水平均高于对照组,而高密度脂蛋白胆固醇(HDL-C)、APN水平显著低于对照组(P0.05)。Pearson相关分析结果显示,APN与BMI、TC、TG、UA、LDL-C、SBP、DBP、AST、ALT、腹围呈负相关,而与HDL-C呈正相关。非条件Logistic回归分析显示,ALT(OR=1.058,95%CI 1.008~1.109)与BMI(OR=14.177,95%CI 1.132~1.528)是NAFLD形成的主要危险因素,而血APN水平(OR=0.981,95%CI 0.975~0.987)是NAFLD发生的保护性因素。结论新疆地区维吾尔族血清APN水平降低在NAFLD发病中具有重要意义,其可能在NAFLD发病过程中起保护作用。
[Abstract]:Objective to investigate the changes of serum adiponectin (APN) levels in Uygur adults with non-alcoholic fatty liver (NAFLD) and their correlation with liver enzymes, serum lipids and uric acid. Methods 558 healthy persons were divided into NAFLD group (n = 289) and healthy group (n = 269) according to the results of B-ultrasound. The age, height, weight, body mass index (BMI),) of (WC), waist height ratio (WHtR),) were measured and recorded in detail. Systolic blood pressure (SBP),) and diastolic blood pressure (DBP),) were used to measure liver enzymology, fasting blood glucose (FPG),) and blood lipid (FPG), and serum APN was determined by enzyme linked immunosorbent assay (Elisa) with uric acid (UA),. The risk factors of NAFLD were analyzed by non conditional Logistic regression analysis. Results BMI,WHtR,SBP,DBP, total cholesterol, (TC), triglyceride, (TG), low density lipoprotein cholesterol (LDL-C), (AST), alanine aminotransferase (ALT), FPG, were found in NAFLD patients. The level of UA was higher than that of control group, while the level of high density lipoprotein cholesterol (HDL-C), APN) was significantly lower than that of control group (P0.05). Pearson correlation analysis showed that APN and BMI,TC,TG,UA,LDL-C,SBP,DBP,AST,ALT, were significantly lower than those in control group). Abdominal circumference was negatively correlated with HDL-C. Non-conditional Logistic regression analysis showed that, ALT (OR=1.058,95%CI 1.008 (1.109) and BMI (OR=14.177,95%CI 1.132 ~ 1.528) were the main risk factors for the formation of NAFLD. The serum APN level (OR=0.981,95%CI 0.975, 0.987) was the protective factor of NAFLD. Conclusion the decrease of serum APN level in Xinjiang Uygur nationality has important significance in the pathogenesis of NAFLD, which may play a protective role in the pathogenesis of NAFLD.
【作者单位】：新疆医科大学公共卫生学院;新疆医科大学护理学院;新疆医科大学第一附属医院体检中心;新疆医科大学第一附属医院临床研究院;
【基金】：国家自然科学基金资助(No.81460120)
【分类号】：R575.5

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