环孢素A治疗激素无效型溃疡性结肠炎疗效观察

发布时间：2019-02-19 12:03

【摘要】：目的观察环孢素A治疗激素无效型溃疡性结肠炎的疗效。方法重度溃疡性结肠炎患者29例,常规激素联合柳氮磺胺吡啶治疗7 d病情无缓解。加环孢素A 5 mg/(kg·d)口服,7 d后减量至3 mg/(kg·d),持续服药3个月,在入院当天(T1)、常规治疗7 d(T2)及加用环孢素A 1周(T3)、2周(T4)、4周(T5)、8周(T6)、12周(T7)行Mayo评分。结果本组患者T1~7时Mayo评分分别为(11.49±2.52)、(11.60±3.10)、(8.47±1.29)、(6.01±1.63)、(3.98±1.07)、(4.07±1.34)、(3.69±0.93)分。Mayo评分T5T4T3T2(P均0.05),T1、T2时Mayo评分差异无统计学意义,T5、T6、T7时Mayo评分比较差异无统计学意义。治疗过程中出现转氨酶升高2例,给予保肝对症治疗后肝功能恢复正常。血压升高8例,2例未予处理血压逐渐将至正常范围,6例给予贝那普利治疗后恢复正常。高血脂1例,给予降脂治疗后血脂恢复正常。未见其他不良反应。结论对于激素治疗无效的UC患者,加用环孢素A治疗疗效满意且安全性好。
[Abstract]:Objective to observe the efficacy of cyclosporine A (CSA) in the treatment of steroid ineffectual ulcerative colitis. Methods 29 patients with severe ulcerative colitis were treated with routine hormone combined with sulfadiazine for 7 days without remission. Cyclosporine A 5 mg/ (kg d) was given orally and then decreased to 3 mg/ (kg d), for 3 months. On admission day (T1), routine therapy was performed on 7 days (T2) and cyclosporine A 1 week (T3), 2 weeks (T4). Mayo scores were assessed at 4 weeks (T 5), 8 weeks (T 6) and 12 weeks (T 7). Results the Mayo scores of T1-7 were (11.49 卤2.52), (11.60 卤3.10), (8.47 卤1.29), (6.01 卤1.63), (3.98 卤1.07), (4.07 卤1.34), respectively. (3. 69 卤0. 93). There was no significant difference in Mayo score at T 1 and T 2, and no significant difference in Mayo score at T 5, T 6 and T 7 in Mayo score (P 0. 05) and T 1 T 2 score (P 0. 05). Transaminase elevation occurred in 2 cases during the treatment. Liver function returned to normal after liver preservation therapy. There were 8 cases of elevated blood pressure, 2 cases were not treated, and 6 cases returned to normal after benazepril treatment. Hyperlipidemia was found in 1 case, which returned to normal after hypolipidemic treatment. No other adverse reactions were observed. Conclusion Cyclosporine A is effective and safe for UC patients who have no effect of hormone therapy.
【作者单位】：临沂市中医医院;
【分类号】：R574.62

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