巨噬细胞在β肾上腺素受体过度激活致肝脏纤维化过程中的研究进展
发布时间：2019-03-22 09:49
【摘要】：机体作为一个复杂的微环境,各个脏器之间是否正常运作具有紧密的关联。已知心力衰竭可以引起肝功能障碍,那么肝脏疾病是否对心功能也有影响并不明确。肝脏纤维化是目前慢性肝脏疾病发展为肝硬化必经之阶段,而β肾上腺素受体(β-adrenergic receptor,β-AR)的功能改变与纤维化密切相关,且巨噬细胞在脏器纤维化的发生发展中有着不可替代的作用。已知β肾上腺素受体激动剂可以通过作用于机体免疫细胞上的β肾上腺素受体发挥作用,进而引起相应脏器的免疫功能紊乱,并最终诱导纤维化的发生。本文对肝功能障碍和心功能损伤的关系,β肾上腺素受体过度激活在肝损伤和心功能障碍中的影响,以及巨噬细胞在其中发挥的作用加以综述。
[Abstract]:As a complex micro-environment, the body is closely related to the normal operation of the organs. It is known that heart failure can cause liver dysfunction, and whether the liver disease has an effect on the heart function is not clear. Liver fibrosis is the first stage of the development of chronic liver disease, and the changes of the function of the Adrenaline receptor (P-AR) are closely related to the fibrosis, and the macrophage plays an irreplaceable role in the development of organ fibrosis. Adrenaline receptor agonists are known to function by the epinephrine receptor acting on the immune cells of the body, thereby causing an immune function disorder of the corresponding organ, and ultimately inducing the occurrence of fibrosis. In this paper, the relationship between liver function and heart function injury, the effect of the over-activation of Adrenaline receptor on the liver injury and the function of heart function, and the role of the macrophage in it are reviewed.
【作者单位】： 首都医科大学基础医学院生理学与病理生理学系;
【基金】：科技部(973计划前期研究专项,2014CB560700) 国家自然科学基金(81271165) 北京市自然科学基金(7142019)资助课题
【分类号】：R575.2
，
本文编号：2445486
[Abstract]:As a complex micro-environment, the body is closely related to the normal operation of the organs. It is known that heart failure can cause liver dysfunction, and whether the liver disease has an effect on the heart function is not clear. Liver fibrosis is the first stage of the development of chronic liver disease, and the changes of the function of the Adrenaline receptor (P-AR) are closely related to the fibrosis, and the macrophage plays an irreplaceable role in the development of organ fibrosis. Adrenaline receptor agonists are known to function by the epinephrine receptor acting on the immune cells of the body, thereby causing an immune function disorder of the corresponding organ, and ultimately inducing the occurrence of fibrosis. In this paper, the relationship between liver function and heart function injury, the effect of the over-activation of Adrenaline receptor on the liver injury and the function of heart function, and the role of the macrophage in it are reviewed.
【作者单位】： 首都医科大学基础医学院生理学与病理生理学系;
【基金】：科技部(973计划前期研究专项,2014CB560700) 国家自然科学基金(81271165) 北京市自然科学基金(7142019)资助课题
【分类号】：R575.2
，
本文编号：2445486
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