肠道微环境与肝脏疾病

发布时间：2019-05-12 08:19

【摘要】：肝脏在行使其消化代谢功能的同时还有一系列的免疫调控机制,以保持免疫耐受,阻止来自肠道的有害刺激进入全身的血液循环。肠道中富含微生物抗原和代谢产物的回流血会通过门静脉进入肝脏,正常生理条件下,肝脏会清除回流血中潜在的危险信号,维持免疫耐受,保持稳态。一旦既有的平衡状态被打破,肠道微生物环境改变,经回流血进入肝脏的肠道的微生物抗原便会引发肝脏中的炎症反应,持续的炎症刺激使肝脏发生病理损伤并导致更为严重的肝脏疾病。本文论及三种不同种类的肝脏疾病以及肝脏疾病演化的三个不同阶段,总结了近几年关于肠道微环境在肝脏疾病发生发展的过程中所发挥作用的最新研究成果,以为更加全面的认识肝脏疾病的发病机制,从而制定更加完善的诊断治疗方案提供理论线索。
[Abstract]:While the liver exercises its digestive and metabolic functions, it also has a series of immune regulation mechanisms to maintain immune tolerance and prevent harmful stimuli from the intestinal tract from entering the blood circulation of the whole body. The reflux blood rich in microbial antigens and metabolites in the intestine will enter the liver through the portal vein. Under normal physiological conditions, the liver will remove the potential dangerous signals from the returned blood, maintain immune tolerance and maintain homeostasis. Once the existing balance is broken and the intestinal microbial environment changes, the microbial antigens in the intestines that bleed back into the liver will trigger inflammation in the liver. Persistent inflammatory stimulation causes pathological damage to the liver and leads to more serious liver disease. In this paper, three different kinds of liver diseases and three different stages of the evolution of liver diseases are discussed, and the latest research results on the role of intestinal microenvironment in the occurrence and development of liver diseases in recent years are summarized. In order to understand the pathogenesis of liver diseases more comprehensively, so as to formulate a more perfect diagnosis and treatment program to provide theoretical clues.
【作者单位】：中国科学技术大学肝脏免疫学实验室;
【基金】：国家重点基础研究发展计划(“973”计划)(973 Program 2013CB944900) 国家自然科学基金重点项目(81130058,81430034)资助
【分类号】：R575

【共引文献】