雌激素受体αT29C基因多态性与慢性乙型肝炎α干扰素早期应答的相关性研究

发布时间：2020-12-15 23:06

　　背景慢性乙型肝炎是我国常见的慢性传染病之一,严重危害人民健康。慢性乙型肝炎（CHB）抗病毒治疗的长期目标是达到病毒清除、延缓肝脏失代偿、肝硬化和肝细胞癌的进展及其并发症的发生,进而改善生活质量和延长存活时间。在所有的治疗方案中,抗病毒治疗是关键,同时随着个体化抗病毒治疗的推进,抗病毒治疗疗效中预测因素,特别是相关的宿主遗传因素引起了人们的关注。本实验旨在探讨雌激素受体α基因T29C多态性与慢性乙型肝炎患者干扰素-α抗病毒治疗后发生早期应答的相关性。方法对首次使用干扰素-α（IFN-α）抗病毒治疗的100例慢性乙型肝炎患者的早期应答情况进行评估,并采用聚合酶链反应-限制性片段长度多态性法（PCR-RFLP）检测雌激素受体α（ESR1）基因T29C多态性:T/T、T/C和C/C三个基因型,并按照此基因型分组分析了其与IFN-α早期应答的相关性。结果（1）三个基因型组间的性别（χ2 = 1.148,?P = 0.563）、年龄（F = 1.153,? P=0.320）、治疗前ALT水平（F = 0.862,?P = 0.441）、治疗前HBV病毒载量? （Z = 1.961,? P =0.1... 

【文章来源】：安徽医科大学安徽省

【文章页数】：61 页

【学位级别】：硕士

【部分图文】：

PCR-RFLP检测ESR1基因T29C多态性电泳结果

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