类风湿性关节炎合并血小板增多患者血清IL-11、sIL-11R水平变化

发布时间：2018-02-26 02:03

  本文关键词： 白细胞介素 游离白细胞介素受体 类风湿关节炎 血小板增多症　出处：《山东医药》2017年35期 　论文类型：期刊论文

【摘要】：目的观察类风湿性关节炎(RA)合并血小板增多患者血清白细胞介素11(IL-11)、游离白细胞介素11受体(s IL-11R)水平的变化。方法将60例RA患者根据血小板计数(PLT)是否300×109/L,分为血小板升高组24例和血小板正常组36例,另选健康体检者30例为对照组,采用ELISA法检测三组患者血清IL-11、s IL-11R。分析RA患者血清IL-11、s IL-11R与PLT、平均血小板体积(MPV)、血小板分布宽度(PDW)、降钙素原(PCT)、RA患者病情评分(DAS28评分)、血沉(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、抗环氨酸肽抗体(ACCP)的相关性。结果血小板增多组血清IL-11、s IL-11R水平均高于血小板正常组和正常组(P均0.05)。RA组患者血清IL-11水平与s IL-11R、PLT、PCT、DAS28、ESR、CRP呈正相关(P均0.05),与MPV、PDW、RF、ACCP无相关性(P均0.05);RA组血清s IL-11R水平与PLT、PCT、DAS28、ESR、CRP、RF、ACCP均呈正相关(P均0.05)。结论 RA合并血小板增多患者血清IL-11、s IL-11R水平明显升高。
[Abstract]:Objective to observe the changes of serum levels of interleukin-11 (IL-11) and free interleukin-11 receptor (IL-11R) in patients with rheumatoid arthritis (RA) complicated with thrombocytosis. Methods 60 patients with RA were divided into small blood according to whether the platelet count was 300 脳 10 9 / L or not. There were 24 cases in the plate elevation group and 36 cases in the normal platelet group. 30 healthy persons were selected as control group. Serum IL-11s IL-11R was measured by ELISA method. Serum IL-11s IL-11R and IL-11R, mean platelet volume (MPV), platelet distribution width (PDWN), calcitonin (PPC) were measured in three groups of patients with RA, and the scores of DAS28, erythrocyte sedimentation rate (ESR) and ESR-C-reactive protein (CRPP-CRPN), rheumatoid factor (RF) were analyzed. Results the levels of serum IL-11s IL-11R in patients with thrombocytosis were higher than those in normal platelet group and normal group (P < 0.05). There was a positive correlation between the level of serum IL-11 and the level of serum IL-11 in patients with IL-11RPLTT and PCTAS28ESRA (P < 0.05), and there was no correlation between serum IL-11s IL-11R and MPVPDWRFCCP (P < 0.05) in patients with RA. There was a positive correlation between the levels of serum s IL-11R and IL-11R in patients with RA complicated with thrombocytosis. Conclusion the levels of IL-11s IL-11R in patients with RA complicated with thrombocytosis were significantly increased.
【作者单位】： 青海大学研究生院;淄博第一医院;青海大学附属医院;
【基金】：中西部高校综合实力提升工程建设项目(4056051001) 青海省科技创新能力促进计划项目(2015-HZ-810)
【分类号】：R558.3;R593.22
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本文编号：1536049