不同分割剂量治疗鼻咽癌的效果比较

发布时间：2017-12-27 00:13

本文关键词：不同分割剂量治疗鼻咽癌的效果比较　出处：《广东医学》2015年08期 　论文类型：期刊论文

【摘要】：目的比较同步整合加量调强放疗(SIB-IMRT)分割剂量2.33 Gy与2.20 Gy治疗鼻咽癌的安全性、有效性。方法比较采用SIB-IMRT分割剂量2.20 Gy/总剂量70.40 Gy(2.20组)与分割剂量2.33 Gy/总剂量69.90 Gy(2.33组)治疗鼻咽癌的近期不良反应、近远期疗效。结果 2.20组112例,2.33组105例,中位随访分别为23、24个月,两组3~4级放射性皮肤、口腔黏膜反应发生率为3.57%和7.62%(P=0.19)及5.36%和11.43%(P=0.08);治疗结束时局部和区域完全缓解率为66.07%、70.47%(P=0.49)。两组1、2、3年的局部控制率为100%、97%、93%和100%、98%、98%(P=0.23);区域控制率为100%、98%、98%和98%、98%、98%(P=0.90);无远处转移控制率为94%、89%、89%和96%、90%、90%(P=0.82);总生存率为97%、94%、94%和99%、92%、85%(P=0.38)。结论 SIB-IMRT分割剂量2.33 Gy与2.20 Gy的放疗方案疗效相当,是一种安全有效的放疗方式。
[Abstract]:Objective to compare the safety and effectiveness of 2.33 Gy and 2.20 Gy in the treatment of nasopharyngeal carcinoma with synchronized integrated plus intensity modulated radiation therapy (SIB-IMRT). Methods the short-term and long-term effects of SIB-IMRT split dose 2.20 Gy/, total dose 70.40 Gy (2.20 groups) and split dose 2.33 Gy/ total dose 69.90 Gy (2.33 group) on nasopharyngeal carcinoma were compared. The results of 2.20 groups of 112 cases, 2.33 groups of 105 cases, the median follow-up was 23, 24 months, two groups of 3~4 radioactive skin, oral mucosa reaction rate was 3.57% and 7.62% (P=0.19) and 5.36% and 11.43% (P=0.08); at the end of the treatment of local and regional complete remission rate was 66.07% (P=0.49, 70.47%). Local control two group 1, 2, 3 years were 100%, 97%, 93% and 100%, 98%, 98% (P=0.23); regional control rate was 100%, 98%, 98% and 98%, 98%, 98% (P=0.90); no metastasis control rate was 94%, 89%, 89% and 96%, 90%, 90% (P=0.82); the total survival rate was 97%, 94%, 94% and 99%, 92%, 85% (P=0.38). Conclusion the therapeutic effect of SIB-IMRT dose 2.33 Gy and 2.20 Gy is quite effective. It is a safe and effective method of radiotherapy.
【作者单位】：汕头大学医学院附属医院放疗科;
【分类号】：R739.63
【正文快照】： 放疗是非转移性鼻咽癌的主要治疗手段,同步整合加量调强放疗(simultaneous integrated boost intensity-modulated radiotherapy,SIB-IMRT)因其物理剂量学及生物学优势已广泛应用于鼻咽癌放疗,其临床研究以分割剂量2.12 Gy/2.20 Gy、总剂量70 Gy左右的放疗方案多见,2年局部控

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