IL-13基因多态性与喉癌遗传易感性的关联研究

发布时间：2017-12-31 16:16

  本文关键词：IL-13基因多态性与喉癌遗传易感性的关联研究　出处：《南京医科大学学报(自然科学版)》2014年05期 　论文类型：期刊论文

  更多相关文章： 喉癌 多态性 单核苷酸 白细胞介素(IL-) 基因 易感性

【摘要】：目的 :探讨白细胞介素-13(interleukin-13,IL-13)基因单核苷酸多态性(single-nucleotide polymorphism,SNP)与喉癌遗传易感性的关系。方法:通过病例-对照研究设计,以111例经病理确诊的喉癌患者和340例健康对照者为研究对象,选取IL-13基因3’-UTR的SNP位点rs1295685,采用TaqMan探针方法进行多态性检测,应用Logistic回归计算OR值及其95%CI,比较不同基因型与喉癌发病风险的关联。结果:病例组与对照组中rs1295685(IL-13C870T)位点基因型分布存在统计学差异,在调整年龄、吸烟、饮酒及肿瘤家族史因素后发现,与CC基因型相比,携带TT/CT基因型者喉癌发病风险显著增高(调整OR值为2.00,95%CI为1.23~3.27,P值为0.005)。与CC基因型相比,携带TT/CT基因型在年龄≤62岁、吸烟、饮酒、无肿瘤家族史各亚组中表现出更高的喉癌患病风险(OR=2.72,95%CI:1.40~5.28;OR=2.07,95%CI:1.19~3.58;OR=1.96,95%CI:1.03~3.73;OR=2.01,95%CI:1.18~3.41)。吸烟、饮酒均与TT/CT基因型存在协同作用(OR=6.48,95%CI:2.77~15.14和OR=7.35,95%CI:3.15~17.12)。而基因型分布在肿瘤分期、分级中未见显著差异。结论:IL-13基因rs1295685位点的单核苷酸多态性与喉癌遗传易感性有关联。
[Abstract]:Objective: to investigate interleukin-13 (IL-13). IL-13) gene single-nucleotide polymorphism. The relationship between SNPs and genetic susceptibility of laryngeal carcinoma methods: 111 patients with laryngeal carcinoma and 340 healthy controls were studied by a case-control study. The polymorphism of SNP locus rs1295685 of IL-13 gene was detected by TaqMan probe method. The OR and 95 CI were calculated by Logistic regression. Results: the genotype distribution of rs1295685 IL-13C870T locus was significantly different between the case group and the control group. After adjusting for age, smoking, alcohol consumption and family history of cancer, it was found that compared with CC genotype, the risk of laryngeal cancer in patients with TT/CT genotype was significantly higher (adjusted OR = 2.00). 95 CI was 1.23 ~ 3.27 (P = 0.005). Compared with CC genotype, the age of carrying TT/CT genotype was 鈮，

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