阻塞性睡眠呼吸暂停低通气综合征与年龄对睡眠结构的影响

发布时间：2018-01-06 19:24

本文关键词：阻塞性睡眠呼吸暂停低通气综合征与年龄对睡眠结构的影响　出处：《南方医科大学学报》2015年06期 　论文类型：期刊论文

【摘要】：目的分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与年龄分别对睡眠结构的影响及持续气道正压通气(CPAP)的治疗效果。方法回顾性分析222例因睡眠打鼾行多导睡眠监测(PSG)的患者,并于次日在PSG下行CPAP治疗,分别控制呼吸暂停低通气指数(AHI)及年龄后,比较不同年龄组以及不同严重度OSAHS组的睡眠结构,并比较OSAHS患者CPAP治疗后睡眠结构、通气功能的变化。结果 N3睡眠与AHI的相关性最大(r=-0.361),REM睡眠及睡眠觉醒与年龄的相关性最大(r=-0.211,0.216)。四年龄组的AHI无显著差异下(P=0.185),睡眠效率、N1、N2及REM睡眠、睡眠觉醒差异有统计学意义(P0.001,P=0.015,0.013,0.030,0.001)。随年龄增加,REM睡眠减少,睡眠觉醒增加。控制AHI后,睡眠效率及睡眠结构差异有统计学意义。不同严重度OSAHS组中,控制年龄后,患者的N1、N2及N3睡眠差异有统计学意义(P=0.011,0.017,0.001)。中重度OSAHS患者N3睡眠随AHI增加而减少。OSAHS患者CPAP治疗后,N1及N2睡眠显著减少,N3及REM睡眠显著增加,所有P0.001。结论 OSAHS与年龄相比,REM睡眠及睡眠觉醒受年龄影响较大,N3睡眠受OSAHS影响较大,CPAP治疗可改善OSAHS患者的睡眠。
[Abstract]:Objective to analyze the effects of OSAHS and age on sleep structure in obstructive sleep apnea hypopnea syndrome (OSAHS) and continuous positive airway pressure (CPAP). Methods 222 patients with PSG were treated with polysomnography because of sleep snoring. The next day CPAP treatment was performed at PSG to control apnea hypopnea index (AHI) and after age. The sleep structure of different age groups and different severity OSAHS groups were compared. The changes of sleep structure and ventilation function in patients with OSAHS after CPAP treatment were compared. Results the correlation between N3 sleep and AHI was most significant (r = 0.361). The correlation between REM sleep and sleep arousal and age was greatest. The AHI in the four age groups had no significant difference, and the sleep efficiency was N 1. 1. There was significant difference in sleep arousal between N2 and REM sleep (P 0.001). REM sleep decreased with age. Sleep arousal increased. After AHI control, there were significant differences in sleep efficiency and sleep structure. In OSAHS group with different severity, the N1 of patients after controlling age was significantly different. The difference of N 2 and N 3 sleep was statistically significant (P < 0.05). N3 sleep decreased with the increase of AHI in moderate and severe OSAHS patients. N1 and N2 sleep decreased significantly after CPAP treatment in patients with OSAHS. N3 and REM sleep increased significantly, all P0.001.Conclusion compared with age, OSAHS sleep and sleep awakening are more affected by age and N3 sleep is more affected by OSAHS. CPAP treatment can improve sleep in OSAHS patients.
【作者单位】：南方医科大学南方医院睡眠医学中心;南方医科大学第三附属医院呼吸科;
【基金】：十二五国家科技支撑计划(2012BAI05B03) 广东省科技计划项目(2012B031800467,2011B090400378)~~
【分类号】：R766
【正文快照】： 阻塞性睡眠呼吸暂停低通气综合征(obstructivesleep apnea hypopnea syndrome,OSAHS)已是国际公认的主要公共卫生问题之一,与高血压、脑卒中、2型糖尿病等相关[1],OSAHS患病率高达4.1%[2]。经鼻持续气道正压通气(continuous positive airway pressure,CPAP)是治疗OSAHS的首选

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