后天性感音神经性聋患者听觉中枢磁共振弥散张量成像研究

发布时间：2018-01-17 15:13

本文关键词：后天性感音神经性聋患者听觉中枢磁共振弥散张量成像研究　出处：《听力学及言语疾病杂志》2015年02期 　论文类型：期刊论文

【摘要】：目的探讨后天性感音神经性聋(sensorineural hearing loss,SNHL)及其病程对听觉中枢白质的影响。方法选后天性SNHL患者30例,根据发病时间分为突发性聋组15例和病程2年以上的SNHL组15例;并选择15例同期行MRI检查的听力正常的其它患者为对照组;运用磁共振弥散张量成像(diffusion tensor imaging,DTI)技术观察各组受试者听觉中枢下丘和外侧丘系的弥散相关参数,包括:部分各向异性(factional anisotropy,FA)值、径向弥散(radial diffusivity,RD)、轴向弥散(axial diffusivity,AD)及平均弥散(mean diffusivity,MD)。结果突聋组、病程2年以上的SNHL组及对照组双侧下丘FA值大小依次为SNHL组对照组突聋组(P0.05),对照组和突聋组与2年以上SNHL组间差异均有统计学意义(P0.05);外侧丘系右侧RD值大小依次为突聋组对照组SNHL组(P0.05),右侧MD值大小依次为对照组突聋组SNHL组,且两两比较差异均有统计学意义(P0.05)。三组下丘及外侧丘系AD值差异无统计学意义(均P0.05)。结论突聋患者的听觉中枢未发生明显异常的改变,而病程大于2年以上的后天性SNHL患者听觉中枢神经纤维束明显受到破坏,提示感音神经性听觉损失患者的病程长短对听觉传导通路的结构变化有影响。
[Abstract]:Objective to investigate the sensorineural hearing loss of acquired sensorineural hearing loss. Methods Thirty patients with acquired SNHL were divided into sudden deafness group (n = 15) and SNHL group (n = 15). 15 patients with normal hearing were selected as control group. The diffusion-related parameters of inferior colliculus and lateral colliculus were observed by diffusion-diffusion Zhang Liang diffusion tensor imaging technique. These include: partial anisotropic anisotropic FAs, radial diffusive RD). Axial diffusive diffusion (ADA) and mean diffusive mean diffusivity (MDN). Results sudden deafness was observed in patients with sudden deafness. The FA value of bilateral inferior colliculus in SNHL group and control group with the course of more than 2 years was SNHL group, sudden deafness group (P0.05). There were significant differences between the control group and the sudden deafness group and the SNHL group for more than 2 years (P 0.05). The right Rd value of lateral colliculus was in order as follows: sudden deafness group, control group, SNHL group, and right side MD value, in turn, SNHL group of sudden deafness group. There was no significant difference in AD between the inferior colliculus and lateral colliculus in the three groups (all P 0.05). Conclusion there is no obvious abnormal change of auditory center in patients with sudden deafness. However, in acquired SNHL patients whose course of disease was longer than 2 years, the auditory central nervous fiber bundle was obviously damaged, suggesting that the duration of the course of the patients with sensorineural hearing loss had an effect on the structural changes of auditory conduction pathway.
【作者单位】：西安交通大学医学院第二附属医院耳鼻咽喉头颈外科;西安交通大学医学院第二附属医院影像科;
【基金】：国家自然科学基金(81271068) 陕西省科技攻关项目(2012K14-02-01) 西安交大第二附属医院科研青年基金项目(YJ(QN)200913) 教育部博士点基金(20120201110060)资助
【分类号】：R764.431
【正文快照】： 1西安交通大学医学院第二附属医院耳鼻咽喉头颈外科(西安710004);2西安交通大学医学院第二附属医院影像科磁共振弥散张量成像(diffusion tensor ima-ging,DTI)能够直接显示活体脑白质神经纤维束在空间的走行、分布和病理变化[1],现已有研究将其应用于视觉传导通路的研究[2,3]

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