紫外光核黄素诱导角膜交联治疗感染性角膜炎的临床研究

发布时间：2018-01-18 04:19

本文关键词：紫外光核黄素诱导角膜交联治疗感染性角膜炎的临床研究　出处：《中华医院感染学杂志》2014年24期 　论文类型：期刊论文

【摘要】：目的研究应用紫外光核黄素诱导角膜交联治疗感染性角膜炎的临床疗效,为临床治疗提供参考依据。方法选取2010年1月-2013年1月入院诊治的感染性角膜炎患者73例,感染性角膜炎87只眼,将所有患者随机分为试验组44只眼和对照组43只眼;试验组患者应用紫外光核黄素诱导角膜交联治疗感染性角膜炎,对照组应用常规药物治疗,观察两组患者治疗效果、视力预后,采用SPSS17.0进行统计分析。结果试验组中痊愈13只眼,好转22只眼,总有效79.55%;对照组痊愈8只眼,好转20只眼,总有效率为65.12%;两组差异有统计学意义(P0.05);试验组治疗后视力在0.6以上者占43.18%,1.0以上者占18.18%;对照组分别占30.23%、9.31%,两组差异有统计学意义(P0.05)。结论应用紫外光核黄素诱导角膜交联治疗感染性角膜炎的疗效显著,患者视力显著提高,可为临床诊治提供一定的参考。
[Abstract]:Objective to study the clinical effect of ultraviolet photoriboflavin induced corneal cross-linking in the treatment of infectious keratitis. Methods from January 2010 to January 2013, 73 patients with infectious keratitis, 87 eyes with infectious keratitis, were selected. All the patients were randomly divided into trial group (44 eyes) and control group (43 eyes). The patients in the experimental group were treated with ultraviolet light riboflavin induced corneal cross-linking for infectious keratitis, while the control group were treated with routine medicine. The therapeutic effect and the prognosis of visual acuity were observed in the two groups. Results in the experimental group, 13 eyes were cured, 22 eyes were improved, the total effective rate was 79.55; In the control group, 8 eyes were cured, 20 eyes were improved, the total effective rate was 65.12%. The difference between the two groups was statistically significant (P 0.05). In the experimental group, the visual acuity was better than 0.6, accounting for 43.18% and higher than 1.0, 18.18%; The control group accounted for 30.23 and 9.31, the difference between the two groups was statistically significant (P 0.05). Conclusion the therapeutic effect of corneal cross-linking induced by ultraviolet riboflavin on infectious keratitis is significant. The visual acuity of the patients was improved significantly, which could provide some reference for clinical diagnosis and treatment.
【作者单位】：郑州人民医院眼科;
【基金】：国家自然科学基金资助项目(11204277) 郑州市卫生局基金资助项目(ZW-2009B-017)
【分类号】：R772.21
【正文快照】： 感染性角膜炎是因细菌、病毒等病原体侵入角膜引起的炎症,患眼有异物感、刺痛甚至烧灼感,球结膜表面混合性充血,伴有怕光、流泪、视力障碍和分泌物增加等症状。该病是主要的致盲性眼病之一,发病率与致盲率均较高,严重者需要摘除眼球。并且感染的病原体种类较多,如细菌、病毒、

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