老年原发性开角型青光眼的复合制剂个性化治疗效果

发布时间：2018-01-19 01:10

本文关键词： 原发性开角型青光眼复合制剂个性化治疗视敏度眼压　出处：《中国老年学杂志》2014年11期 　论文类型：期刊论文

【摘要】：目的探讨老年原发性开角型青光眼(POAG)的复合制剂个性化治疗效果。方法回顾性分析2011年1月至2013年8月河北联合大学附属医院眼科收治的40例POAG患者的临床资料,随机分为4组(n=10),另外选择同期于我院40例健康体检者作为对照组。比较治疗前后视力、视敏度、视敏度缺损值、眼压(IOP)、视诱电位、治疗6 w后8 am、10 am、4 pm、8 pm、12 pm、次日4 am和8 am时IOP测定值、双眼峰时频数分布及正常对照组与患者组治疗6 w后峰值眼压、谷值眼压、平均眼压及眼压波动值。结果 (1)治疗前后视力、视敏度、视敏度缺损值、IOP、诱发电位振幅及诱发电位潜伏期相比,差异均具有统计学意义(P0.05,P0.01);(2)治疗6 w后8 am时IOP出现峰值,8 pm时IOP出现谷值,且各时间点IOP测定值与正常对照组相比,差异均无统计学意义(P0.05);(3)治疗6 w后4 am时峰时分布例数最多(9例),占22.50%;8 pm时峰时分布例数最少(2例),占5.00%;(4)治疗6 w后POAG患者右眼、左眼及双眼峰值眼压、谷值眼压、平均眼压及眼压波动值与正常对照组相比,差异均无统计学意义(P0.05)。结论采用复合制剂个性化治疗的方法用于治疗老年原POAG患者,效果显著,值得在临床上加以推广及普及。
[Abstract]:Objective to investigate the primary open-angle glaucoma (Poag) in the elderly. Methods from January 2011 to August 2013, the clinical data of 40 patients with POAG in the affiliated Hospital of Hebei Union University were analyzed retrospectively. Four groups were randomly divided into 4 groups, and 40 healthy persons were selected as control group. The visual acuity, visual acuity, visual acuity defect, IOP and inductive potential were compared before and after treatment. After 6 weeks of treatment, IOP was measured at 8 amps, 10 amps, 4 pm, 8 pm, 12 pm, the next day, 4 am and 8 am. After 6 weeks of treatment, the peak intraocular pressure (IOP), mean intraocular pressure (IOP), mean intraocular pressure (IOP) and intraocular pressure fluctuation (IOP) were observed in the normal control group and the patient group. Results 1) the visual acuity, visual acuity and visual acuity defect before and after treatment. The difference of IOP, amplitude of evoked potential and latency of evoked potential was statistically significant (P 0.05) and P 0.01 (P 0.01). (2) at 8 am after treatment, the peak value of IOP appeared at 8 pm and IOP appeared valley value at 8 pm, and the IOP values at each time point were compared with those of normal control group. The difference was not statistically significant (P 0.05). (3) at 4 am after 6 weeks of treatment, 9 cases (22.50%) had the highest peak time distribution. At 8 pm, the distribution of peak time was the least in 2 cases, accounting for 5.00%. After 6 weeks of treatment, the peak intraocular pressure (IOP), mean intraocular pressure (IOP), mean intraocular pressure (IOP) and intraocular pressure fluctuation (IOP) in patients with POAG were compared with those in the control group. Conclusion it is worth popularizing and popularizing the application of individualized compound preparation in the treatment of elderly patients with POAG.
【作者单位】：承德市中心医院眼科;河北联合大学基础学院;
【分类号】：R775
【正文快照】： 原发性开角型青光眼(POAG)作为常见的一类青光眼,其临床发病多较为隐蔽,进展期较长,往往难以觉察到,因此早期一般无任何症状〔1〕。当病变发展至一定程度的时候,则一般会出现眼胀、视力疲劳以及头痛等方面的临床症状,虽然其病变早期视力未受一定的影响,但视野范围会逐渐缩小,

【参考文献】