多西他赛单药同步放化疗治疗局部晚期鼻咽癌疗效研究

发布时间：2018-01-19 03:19

本文关键词： 多西他赛同步放化疗局部晚期鼻咽癌　出处：《南京医科大学学报(自然科学版)》2014年03期 　论文类型：期刊论文

【摘要】：目的:探讨放疗联合多西他赛单药同步化疗治疗局部晚期鼻咽癌的临床疗效。方法:选取影像及病理证实的局部晚期(T2-3N2-3M0)鼻咽癌68例,其中顺铂[(cis-dichlorodiamineplatinum(Ⅱ),PDD]联合放疗组32例和多西他赛(docetaxel,TXT)联合放疗组36例;放疗均采用调强放疗技术,6/15 MV X线外照射,肿瘤剂量66 Gy。治疗结束后,比较两组近期疗效、总生存率、无进展生存率及不良反应。结果:PDD联合放疗组完全缓解25例,部分缓解7例,TXT联合放疗组完全缓解27例,部分缓解9例,两组比较差异无统计学意义(P=0.762)。两者总生存率、无进展生存率比较亦均无统计学差异(P0.05)。不良反应比较中,TXT联合放疗组仅血液毒性明显高于PDD联合放疗组(P=0.01),但均可控制,其余不良反应比较,两组差异无统计学意义(P0.05)。结论:TXT单药同步放化疗,具有PDD单药同步放化疗相似的近、远期疗效,虽然具有较大的血液毒性,但均在可控范围内,值得在临床上推广运用。
[Abstract]:Objective: to investigate the clinical effect of radiotherapy combined with docetaxel alone in the treatment of locally advanced nasopharyngeal carcinoma (NPC). Methods: 68 cases of locally advanced nasopharyngeal carcinoma (NPC) proved by imaging and pathology were selected. Of which cisplatin. [Cis-dichlorodiamineplatinum (PDD) combined with radiotherapy group (32 cases) and docetaxel (docetaxel). TXT combined with radiotherapy group (36 cases); All patients were treated with intensity modulated radiotherapy (IMRT) and external radiotherapy with a tumor dose of 66 Gy.The short-term curative effect and overall survival rate of the two groups were compared. Results there were 25 cases of complete remission, 7 cases of partial remission and 27 cases of complete remission and 9 cases of partial remission. There was no significant difference between the two groups. The overall survival rate and the progression-free survival rate were not significantly different between the two groups (P 0.05). The blood toxicity of TXT combined with radiotherapy group was significantly higher than that of PDD combined radiotherapy group, but it could be controlled, and the other adverse reactions were compared. There was no significant difference between the two groups (P0.050.Conclusion the PDD single drug chemoradiotherapy is similar in the near and long term, although it has great toxicity in blood. [WT5HZ] [WT5 "HZ] [WT5" BZ] [WT5 "HZ]. But all in controllable range, it is worth popularizing in clinical application.
【作者单位】：南京医科大学附属淮安第一医院肿瘤放疗科;
【分类号】：R739.63
【正文快照】： 鼻咽癌是我国最常见的头颈部恶性肿瘤之一,多发于我国南方,其病死率居我国恶性肿瘤病死率的第8位[1]。因其解剖结构的特殊性,及对放、化疗等敏感性,临床上主要采取单纯放疗或放化综合治疗。而对于局部晚期鼻咽癌,同步放化疗是其标准的治疗方案。对于同步化疗的药物,目前临床上

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