儿童疱疹性咽峡炎急性期T细胞亚群和免疫球蛋白变化

发布时间：2018-01-19 10:03

本文关键词： 疱疹 T细胞亚群免疫球蛋白补体C3、C4　出处：《青岛大学》2011年硕士论文　论文类型：学位论文

【摘要】：目的探讨对疱疹性咽峡炎患儿进行CD3+、CD4+、CD8+淋巴细胞和IgG、IgA、IgM及补体C3、C4检测的临床意义。方法采用流式细胞仪技术检测30例疱疹性咽峡炎患儿外周血CD3+、CD4+、CD8+淋巴细胞含量,采用免疫比浊法检测IgG、IgA、IgM及补体C3、C4的含量,及30例正常健康儿童外周血CD3+、CD4+、CD8+淋巴细胞,IgG、IgA.IgM及补体C3、C4的含量变化。结果疱疹性咽峡炎患儿组与健康儿童组比较,CD3+、CD8+明显增高,统计学显示差异有显著性统计学意义(P0.05),CD4+及CD4+/CD8+比值均明显降低,统计学显示差异有显著性统计学意义(P0.01),IgG、IgA、IgM含量均明显降低,统计学显示差异有显著性统计学意义(P0.001),补体C3、C4的含量无明显变化,无统计学意义(P0.05)。结论疱疹性咽峡炎患儿存在细胞免疫和体液免疫功能失调。分析血清免疫球蛋白的降低可能与辅助诱导性T细胞亚群(CD4+)的减少和T抑制细胞(CD8+)数量增多有关。疱疹性咽峡炎患儿血清补体C3、C4含量无明显变化(P0.05),无统计学差异,提示血清补体在疾病发病过程中未起主导作用。
[Abstract]:Objective to study the CD3 CD4 + CD8 lymphocytes, IgGG + IgA + IgM and complement C3 in children with herpes isthmus. Methods flow cytometry was used to detect the CD _ 4 and CD _ 8 lymphocytes in peripheral blood of 30 children with herpes spondylitis. The levels of IgG CD3 IgM and complement C 3 C 4 in peripheral blood of 30 healthy children were detected by immunoturbidimetric method, and the levels of CD 4 and CD 8 lymphocytes in peripheral blood of 30 healthy children were measured. Results the levels of CD3 and CD8 in children with herpes isthmus were significantly higher than those in healthy children. The difference was statistically significant (P 0.05) and the ratio of CD4 / CD 8 was significantly decreased (P 0.01). The level of IgA- IgM in IgGG was significantly decreased, the difference was statistically significant (P 0.001), and the content of complement C _ 3 C _ 4 had no significant change. Conclusion there are cellular and humoral immune disorders in children with herpetic pharyngitis. The decrease of serum immunoglobulin may be associated with the auxiliary inducible T cell subsets (P < 0.05). The decrease of CD4 was related to the increase in the number of T suppressor cells and CD8). The serum complement C3 was found in children with herpes isthmus. There was no significant change in C4 content (P 0.05), indicating that serum complement did not play a leading role in the pathogenesis of the disease.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R766

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