缺氧诱导因子-1α在喉癌中的表达及意义

发布时间：2018-01-19 12:07

本文关键词： 喉癌缺氧诱导因子-α TNM分期免疫组织化学方法　出处：《听力学及言语疾病杂志》2015年05期 　论文类型：期刊论文

【摘要】：目的研究缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)在喉癌中的表达及意义。方法用免疫组织化学方法检测40例喉癌患者标本中缺氧诱导因子-1α的表达,并分析其与患者的年龄、吸烟、饮酒史、TNM分期、有无淋巴结转移等临床因素的相关性。结果肿瘤分期为T3、T4期及有淋巴结转移的喉癌标本中HIF-1α的阳性表达的比例分别为87.5%(14/16)和91.7%(11/12),高于T1、T2期及无淋巴结转移的患者[分别为54.2%(13/24)和57.1%(16/28)](P0.05),而年龄、吸烟饮酒史及喉癌组织类型对HIF-1α表达无影响。结论 HIF-1α阳性高表达与喉癌的T分期和淋巴结转移可能有关。
[Abstract]:Objective to study the hypoxia inducible factor-1 伪 of hypoxia-inducible factor-1 伪. Methods Immunohistochemical method was used to detect the expression of hypoxia inducible factor-1 伪 (HIF-1 伪) in 40 patients with laryngeal carcinoma, and to analyze the relationship between HIF-1 伪 and age and smoking. TNM stage, lymph node metastasis and other clinical factors were correlated. Results the tumor stage was T3. The positive rates of HIF-1 伪 expression in stage T4 and laryngeal carcinoma with lymph node metastasis were 87.5 / 14 / 16) and 91.7 / 12 / 12, respectively, which were higher than those in T1. Patients with stage T2 and no lymph node metastasis. [It's 54.2 / 24 and 57.1 / 16 / 28, respectively. The history of smoking and drinking and the histological type of laryngeal carcinoma had no effect on the expression of HIF-1 伪. Conclusion the high expression of HIF-1 伪 may be related to T stage and lymph node metastasis of laryngeal carcinoma.
【作者单位】：浙江省德清县人民医院耳鼻咽喉科;
【基金】：浙江省德清县科技局(2009Ny01)资助
【分类号】：R739.65
【正文快照】： 肿瘤组织的缺氧状态与肿瘤细胞的浸润、转移及预后差有关[1]。缺氧诱导因子-1(hypoxia in-ducible factor-1α,HIF-1)是一种机体适应低氧或缺氧的重要转录调节因子,其由α和β两个亚基组成,HIF-1β的表达不受细胞氧浓度的调节[2]。*浙江省德清县科技局(2009Ny01)资助1浙江省德

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