调强放疗联合单药顺铂不同化疗方案同期治疗鼻咽癌的急性不良反应比较

发布时间：2018-01-20 02:15

本文关键词： 鼻咽肿瘤顺铂放射疗法高频同期放化疗急性不良反应　出处：《肿瘤防治研究》2015年03期 　论文类型：期刊论文

【摘要】：目的比较无远处转移鼻咽癌(nasopharyngeal carcinoma,NPC)调强放疗(intensity-modulated radiotherapy,IMRT)联合单药顺铂每周(40 mg/m2,1次/周)和每3周(80~100 mg/m2,1次/3周)同期放化疗的急性不良反应和治疗前后的营养状况差异。方法回顾分析45例IMRT联合单药顺铂同期化疗的非转移NPC患者临床资料,急性不良反应评估采用CTCAE 3.0标准,不良反应和营养状况统计分析采用t检验、卡方分析或精确概率法以及方差分析检验。结果 45例患者口干、咽痛、口腔黏膜炎、皮炎、恶心、呕吐及骨髓抑制3~4级不良反应发生率分别为6.7%、15.6%、28.9%、6.7%、8.9%、13.3%和22.2%。治疗后BW、BMI、TP、BUN、Cr、Na+、K+、Ca2+和Cl-变化的性别分层方差分析差异均无统计学意义(P0.05),ALB变化接近统计学意义。组内分析显示两组治疗后ALB、TP、Na+和Cl-均下降(P0.05),但顺铂每周组BW、BMI下降更明显(P0.05)。结论治疗前后两组营养状况均有不同程度下降,顺铂每周组营养失衡较顺铂每3周组更普遍,但治疗前后两组变化无明显差异。
[Abstract]:Objective to compare nasopharyngeal carcinoma without distant metastasis. NPC-intensity-modulated radiation therapy (IMRT) combined with cisplatin 40 mg/m2 per week. Once a week) and every 3 weeks. Methods the clinical data of 45 patients with non-metastatic NPC treated with IMRT combined with cisplatin were retrospectively analyzed. CTCAE 3.0 was used to evaluate acute adverse reactions, and t test was used for statistical analysis of adverse reactions and nutritional status. Results 45 patients with xerostomia, pharyngitis, oral mucositis, dermatitis, nausea. The incidence of adverse reactions in grade 3 of vomiting and bone marrow suppression were 6.70.15.6and 28.9and 6.78.9respectively. The incidence of BWBMI after treatment was 13.3% and 22.2%, respectively. There was no significant difference in the sex stratified ANOVA of the changes of Ca 2 and Cl-between the two groups (P 0.05). The changes of ALB were close to statistical significance. The results of intragroup analysis showed that the levels of ALB and Cl- in both groups were decreased after treatment (P 0.05), but the weekly BW of cisplatin group was lower than that of control group (P < 0.05). Conclusion before and after treatment, the nutritional status of the two groups decreased in varying degrees, and the nutritional imbalance was more common in the cisplatin weekly group than in the cisplatin every 3 weeks group. However, there was no significant difference between the two groups before and after treatment.
【作者单位】：广西壮族自治区人民医院肿瘤中心放疗科;广西医科大学药学院;
【基金】：国家自然科学基金(81160284)
【分类号】：R730.58;R739.63
【正文快照】： 差分析差异均无统计学意义(P0.05),ALB变化接近统计学意义。组内分析显示两组治疗后ALB、TP、Na+和Cl-均下降(P0.05),但顺铂每周组BW、BMI下降更明显(P0.05)。结论治疗前后两组营养状况均有不同程度下降,顺铂每周组营养失衡较顺铂每3周组更普遍,但治疗前后两组变化无明显差

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