外周血内皮祖细胞在老年突发性耳聋患者中的数量变化及其临床意义

发布时间：2018-01-20 14:14

本文关键词： 听觉丧失突发性干细胞内皮流式细胞术　出处：《重庆医学》2014年13期 　论文类型：期刊论文

【摘要】：目的探讨内皮祖细胞(EPCs)在老年突发性耳聋患者外周血中的数量变化及其临床意义。方法用流式细胞术检测25例老年突发性耳聋患者(老年突发性耳聋组)及10例健康体检者(健康对照组)外周血中EPCs的相对计数及绝对计数,观察患者治疗前后外周血中EPCs数量的变化,分析其变化与患者临床治疗的关系。结果老年突发性患者治疗前外周血EPCs相对计数及绝对计数较健康对照组低,有效治疗后外周血EPCs相对计数及绝对计数较治疗前高,治疗后有效组较无效组外周血EPCs相对计数及绝对计数值高,差异有统计学意义(P0.01)。结论 EPCs计数值随着患者治疗情况的好转而呈现逐渐上升的趋势,患者治愈情况越好,其EPCs相对计数及绝对计数值越高,EPCs相对计数及绝对计数值可以作为老年突发性耳聋患者治疗效果及术后康复的重要评价指标。
[Abstract]:Objective to investigate the quantitative changes and clinical significance of endothelial progenitor cells (EPCs) in peripheral blood of elderly patients with sudden deafness. Methods flow cytometry was used to detect 25 elderly patients with sudden deafness. The relative and absolute counts of EPCs in peripheral blood of 10 healthy persons (healthy control group). The changes of EPCs in peripheral blood were observed before and after treatment. Results the relative and absolute counts of peripheral blood EPCs in the elderly patients with sudden onset before treatment were lower than those in the healthy control group. The relative and absolute counts of peripheral blood EPCs after effective treatment were higher than those before treatment, and the relative and absolute counts of peripheral blood EPCs in the effective group were higher than those in the ineffective group. The difference was statistically significant (P 0.01). Conclusion the value of EPCs increased gradually with the improvement of treatment, and the better the patient was cured. The higher the EPCs relative count and absolute count value, the higher the relative count and absolute count value of EPCs can be used as an important index to evaluate the therapeutic effect and postoperative rehabilitation of elderly patients with sudden deafness.
【作者单位】：重庆市沙坪坝区人民医院耳鼻咽喉科;重庆医科大学第一附属医院耳鼻咽喉科;
【分类号】：R764.437
【正文快照】： 突发性耳聋在人群尤其是老年群体中是一种极为常见的疾病,过去由于医疗条件的不足,突发性耳聋严重困扰着老年患者的日常生活。当前医学认为,突然发生的、可在数分钟、数小时或3d内出现,连续3个频率听力下降30dB以上不明原因感音神经性聋即为突发性耳聋。目前,突发性耳聋具体病

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