线粒体偶联—因子6及其它因素与阻塞性睡眠呼吸暂停低通气综合征关系的研究

发布时间：2018-01-23 08:44

本文关键词： 阻塞性睡眠呼吸暂停低通气综合征心血管疾病代谢紊乱线粒体偶联因子6　出处：《山东大学》2011年硕士论文　论文类型：学位论文

【摘要】：目的了解青岛市居民阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome, OSAHS)的患病率、发病高危因素,探讨OSAHS对高血压和代谢紊乱的影响。方法经随机抽样,对青岛市1856个家庭7030个体进行流行病学问卷调查。随机抽取115例OSAHS患者作为研究对象,选122例健康人为对照组,检测其晨起血压,血糖,血甘油三酯,胆固醇和尿酸等指标。抽取中重度OSAHS患者32例,健康对照20例,采用放射免疫法检测外周血线粒体偶联因子6(CF6)。对其检测结果进行统计学分析,P0.05为有统计学意义。结果打鼾及经常打鼾者2979例,患病率为42.4%,OSAHS患者237例,患病率为3.4%。单因素分析结果表明,年龄、性别、嗜烟、嗜酒、直系亲属打鼾5个因素在组间有统计学差异；多因素分析表明,性别、嗜烟及直系亲属打鼾为影响OSAHS发病的高危因素。OSAHS患者组晨起血压(130.82/85.7±10.26/7.3)mmHg高于对照组(120.23/78.6±9.61/6.03)mmHg;血糖(GLU),总胆固醇(TC),甘油三酯(TG)和尿酸等,均明显高于对照组(P0.05)。中重度OSAHS患者血线粒体偶联因子6(CF6)显著高于正常对照。结论OSAHS患病率随居民年龄的增大而增加；男性较女性更容易患病；肥胖及超重人群的患病率明显高于正常体重人群；有吸烟及嗜酒不良生活习惯者OSAHS的患病率明显高于无该不良嗜好者。直系亲属打鼾人群患病率高于无直系亲属打鼾人群。OSAHS可引起心血管疾病及代谢紊乱,CF6在OSAHS患者引起血压等其它血管病变中可能起着重要的作用。
[Abstract]:Objective to investigate the obstructive sleep apnea-hypopnea syndrome of obstructive sleep apnea hypopnea syndrome (OSAS) in Qingdao. Objective: to investigate the effect of OSAHS on hypertension and metabolic disorder. Methods A questionnaire survey was conducted on 1 030 individuals from 1 856 families in Qingdao by random sampling. 115 OSAHS patients were randomly selected as the subjects. The morning blood pressure, blood glucose, triglyceride, cholesterol and uric acid were measured in 122 healthy persons as control group. 32 patients with moderate and severe OSAHS and 20 healthy controls were selected. Radioimmunoassay (RIA) was used to detect the mitochondrial coupling factor 6 (CF6) in peripheral blood and the results were statistically analyzed (P0.05). Results there were 2979 cases of snoring and frequent snoring, the prevalence rate was 42.4% OSAHS, and the prevalence rate was 3.4%. The results of univariate analysis showed that age, sex, smoking, alcoholism. The five factors of snoring in the direct relatives were statistically different among the groups. Multivariate analysis showed that sex. Smoking and snoring of direct relatives were the high risk factors for the onset of OSAHS. The blood pressure of patients with OSAHS was 130.82% 85.7 卤10.26% 7.3mmHg higher than that of control group (P < 0.05). 120.23% 78.6 卤9.61% 6.03mm Hg; Blood glucose, total cholesterol, triglyceride (TGG) and uric acid. It was significantly higher in patients with moderate and severe OSAHS than that in the control group (P 0.05), and in patients with moderate and severe OSAHS, the level of plasma mitochondrial coupling factor 6 (CF6) was significantly higher than that in normal controls. Conclusion the prevalence of OSAHS increases with the age of residents. Men are more likely than women to get sick; The prevalence of obesity and overweight was significantly higher than that of normal weight. The prevalence of OSAHS in patients with smoking and poor drinking habits was significantly higher than that in those without such bad habits. The prevalence of snoring in direct relatives was higher than that in those without direct family snoring. And metabolic disorders. CF6 may play an important role in other vascular diseases such as blood pressure in patients with OSAHS.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R766

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