咽喉反流对声门型喉癌中COX-2mRNA表达的影响

发布时间：2018-01-30 14:30

本文关键词： 环加氧酶咽喉反流声门型喉癌　出处：《临床耳鼻咽喉头颈外科杂志》2014年06期 　论文类型：期刊论文

【摘要】：目的:探讨咽喉反流对环加氧酶2(COX-2)mRNA在声门型喉癌病变黏膜中表达的影响。方法:对40例声门型喉癌患者行电子鼻咽喉镜检查、反流检查计分量表(RFS)和反流症状指数量表(RSI)评分,将其分为声门型喉癌反流阳性组(20例)和声门型喉癌反流阴性组(20例),另取10例癌旁2cm以上黏膜组织作为对照组。采用Real-time PCR方法,测定各组黏膜中COX-2mRNA的表达情况。结果:声门型喉癌组COX-2mRNA的表达明显高于对照组(P0.05);声门型喉癌反流阳性组的表达高于声门型喉癌反流阴性组(P0.05)。结论:咽喉反流因素可能通过组织损伤、炎症及细胞恶性转化使声门型喉癌的COX-2mRNA的表达升高。
[Abstract]:Objective: to investigate the effect of laryngeal reflux on the expression of Cyclooxygenase 2OX-2 mRNA in the mucosa of glottic laryngeal carcinoma. Methods: 40 patients with glottic laryngeal carcinoma were examined by electronic nasopharyngoscope. The reflux scoring scale (RFS) and the reflux symptom index (RSI) were divided into two groups: 20 patients with positive reflux of glottic laryngeal carcinoma and 20 patients with negative reflux of glottic laryngeal carcinoma). Another 10 cases of mucosa above 2cm adjacent to carcinoma were taken as control group. Real-time PCR method was used. Results: the expression of COX-2mRNA in glottic laryngeal carcinoma group was significantly higher than that in control group (P 0.05). The expression of reflux positive group in glottic laryngeal carcinoma was higher than that in negative reflux group of glottic laryngeal carcinoma (P 0.05). Conclusion: the factors of pharynx and laryngeal reflux may be caused by tissue injury. Inflammation and malignant cell transformation increase the expression of COX-2mRNA in glottic laryngeal carcinoma.
【作者单位】：中国医科大学附属盛京医院耳鼻咽喉科;
【基金】：辽宁省自然基金(No:20092135) 辽宁省教育厅高校科技研究项目(No:2009A757)
【分类号】：R739.65
【正文快照】： 咽喉反流性疾病(laryngopharyngeal refluxdisease,LPRD)是近年来逐渐被临床认识的一种多发病,是指胃内容物反流至食管上括约肌以上部位,通过胃酸胆盐及胃蛋白酶等直接损伤和刺激迷走神经反射咳嗽导致的机械性损伤所产生的一系列相关疾病。环加氧酶(cyclooxygenase,COX)是催化

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