过氧化氢酶对吸烟相关喉鳞状细胞癌发病的影响

发布时间：2018-02-24 09:10

本文关键词： 氧化应激过氧化氢酶吸烟癌鳞状细胞　出处：《临床耳鼻咽喉头颈外科杂志》2015年15期 　论文类型：期刊论文

【摘要】：目的:探讨氧化应激在吸烟相关喉鳞状细胞癌发生发展中的影响,以及过氧化氢酶(CAT)对吸烟相关喉鳞状细胞癌的临床诊断意义。方法:收集吸烟人群119例,其中吸烟相关喉鳞状细胞癌组68例、非喉鳞状细胞癌人群(对照组)51例,比较2组血浆和癌组织的CAT、丙二醛(MDA)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)、一氧化氮(NO)水平,分析氧化应激指标与吸烟相关喉鳞状细胞癌及其严重程度的关系。结果:1与对照组相比,喉鳞状细胞癌组的吸烟密度、吸烟支数、CAT、MDA、GSH显著升高(均P0.01);而SOD、NO明显下降(均P0.01)。2随着喉鳞状细胞癌组织分化程度越低,血清CAT越高(P0.01),癌组织匀浆的CAT、MDA、GSH也越高(均P0.01),而血清NO则越低(P0.01),癌组织匀浆的SOD、NO越低(均P0.01);喉鳞状细胞癌患者临床分期越高,血清和癌组织的CAT、癌组织的GSH越高(均P0.01),而癌组织NO越低(P0.01)。3血清CAT、MDA为吸烟相关喉鳞状细胞癌发病的独立危险因素(OR=1.060,2.475;P0.01,P0.05)。结论:氧化应激是吸烟人群发生喉鳞状细胞癌的主要影响因素,CAT可作为吸烟相关喉鳞状细胞癌的临床诊断指标。
[Abstract]:Objective: to investigate the effect of oxidative stress on the occurrence and development of smoking associated laryngeal squamous cell carcinoma (LSCC) and the clinical significance of catalase catalase (CAT) in the diagnosis of smoking-related laryngeal squamous cell carcinoma (LSCC). Methods: 119 cases of smoking were collected. The levels of CAT, malondialdehyde (MDA) MDAA, superoxide dismutase (SOD), glutathione glutathione (GSH), nitric oxide (no) in plasma and cancer tissues were compared in 68 patients with smoking associated laryngeal squamous cell carcinoma and 51 patients with non-laryngeal squamous cell carcinoma (control group, n = 51). The relationship between oxidative stress and smoking related laryngeal squamous cell carcinoma (LSCC) and its severity was analyzed. The number of cigarette smoking and the GSH of MDAA were significantly increased (all P 0.01), while the level of SODN decreased significantly (P 0.01 / 2) with the degree of differentiation of laryngeal squamous cell carcinoma (LSCC) decreased. The higher the serum CAT level was, the higher the level of CAT in cancer tissue homogenate was (P 0.01), and the lower the level of serum no was (P 0.01), the lower the level of CAT in cancer tissue homogenate was (P 0.01), the higher the clinical stage was in laryngeal squamous cell carcinoma (LSCC). In serum and cancer tissues, the GSH of cancer tissue was higher than that of cancer tissue (P 0.01), and the lower the no level in cancer tissue was, the lower the level of serum GSH was. The serum GSH was the independent risk factor of smoking related laryngeal squamous cell carcinoma. Conclusion: oxidative stress is an independent risk factor for smoking related laryngeal squamous cell carcinoma. Conclusion: oxidative stress is the occurrence of laryngeal squamous cell carcinoma in smokers. Cat can be used as a diagnostic marker for smoking-related laryngeal squamous cell carcinoma.
【作者单位】：河北北方学院附属第一医院耳鼻咽喉头颈外科;
【分类号】：R739.65

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