鼻咽癌患者血清微小RNA-29c表达的研究

发布时间：2018-02-26 07:17

  本文关键词： microRNA 鼻咽癌 肿瘤 肿瘤分期　出处：《广西医科大学》2011年硕士论文　论文类型：学位论文

【摘要】：目的检测鼻咽非角化型癌患者血清中微小RNA-29c(microRNA-29c,miR-29c)的表达量,探讨miR-29c与鼻咽非角化型癌发生、发展和侵袭转移的关系。 方法鼻咽癌组为24例鼻咽非角化型癌患者,正常组为24例健康人,收集两组的血清,用Q-PCR方法检测血清中miR-29c的表达量。 结果(1)鼻咽非角化型癌患者血清中miR-29c的表达量明显低于健康人血清中miR-29c的表达量(P0.05);(2)有淋巴结转移的鼻咽非角化型癌患者血清中miR-29c的表达量明显低于无淋巴结转移的鼻咽非角化型癌患者血清中miR-29c的表达量(P0.05);(3)鼻咽癌2008分期Ⅳ期的鼻咽非角化型癌患者血清中miR-29c的表达量明显低于Ⅱ-Ⅲ期的鼻咽非角化型癌患者血清中miR-29c的表达量(P0.05);(4)不同性别的鼻咽非角化型癌患者血清中miR-29c的表达量无明显差异(P0.05);(5)不同年龄的鼻咽非角化型癌患者血清中miR-29c的表达量无明显差异(P0.05)。 结论鼻咽非角化型癌患者血清中miR-29c表达量明显降低,有淋巴结转移和临床分期晚的患者血清中miR-29c的表达量更低。提示miR-29c可能与鼻咽癌的发生、发展和侵袭转移有关。
[Abstract]:Objective to detect the expression of microRNA-29cRNA-29cmmiR-29c in the serum of patients with nonkeratinized nasopharyngeal carcinoma, and to investigate the relationship between miR-29c and the occurrence, development, invasion and metastasis of nasopharyngeal non-keratinized carcinoma. Methods Twenty four patients with nasopharyngeal non-keratinized carcinoma and 24 normal controls were enrolled in this study. Serum samples from two groups were collected and the expression of miR-29c was detected by Q-PCR. Results (1) the expression of miR-29c in serum of patients with nonkeratinized nasopharynx carcinoma was significantly lower than that of healthy persons (P 0.05). The expression of miR-29c in patients with non-keratinized nasopharyngeal carcinoma with lymph node metastasis was significantly lower than that in patients without lymph node transformation. Expression of miR-29c in serum of patients with non-keratinized carcinoma of nasopharynx (P0.05P0.05) the expression of miR-29c in patients with stage 鈪，

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