鼻咽癌患者放疗中发生医院感染的危险因素分析

发布时间：2018-02-27 22:04

  本文关键词： 鼻咽癌 放疗 医院感染 危险因素　出处：《中华医院感染学杂志》2014年13期 　论文类型：期刊论文

【摘要】：目的分析鼻咽癌患者放疗中发生医院感染的危险因素,为临床治疗策略的制定提供参考。方法回顾性分析2011年3月-2013年3月行放疗的72例鼻咽癌患者临床资料,统计其医院感染的发生率、感染部位、病原菌的分布及其危险因素;所有数据采用SPSS 17.0软件进行统计分析。结果 72例鼻咽癌患者中有57例发生医院感染,感染率为79.17%;感染部位以口腔黏膜感染最多36例占63.16%,其次是皮肤感染13例占22.81%;检出病原菌57株,以真菌为主38株占66.67%,其次革兰阴性菌13株占22.80%、革兰阳性菌6株占10.53%,检出病原菌前3位依次为白色假丝酵母菌、鲍氏不动杆菌、热带假丝酵母菌,分别占50.88%、10.53%、8.77%;高龄、接受手术治疗、住院30d、应用抗菌药物≥2种以及Ⅲ~Ⅳ期鼻咽癌是鼻咽癌患者放疗中发生医院感染的危险因素。结论鼻咽癌患者容易发生口腔黏膜部的感染,以真菌感染为主,临床上应缩短患者的住院天数,规范进行抗感染治疗,及早发现和控制感染,以减少医院感染的发生,提高患者的临床疗效。
[Abstract]:Objective to analyze the risk factors of nosocomial infection in patients with nasopharyngeal carcinoma (NPC) after radiotherapy, and to provide reference for the formulation of clinical treatment strategies. Methods the clinical data of 72 patients with nasopharyngeal carcinoma treated with radiotherapy from March 2011 to March 2013 were analyzed retrospectively. The incidence of nosocomial infection, the location of nosocomial infection, the distribution of pathogenic bacteria and the risk factors of nosocomial infection were analyzed by SPSS 17.0 software. Results 57 out of 72 patients with nasopharyngeal carcinoma had nosocomial infection. The infection rate was 79.17. The most common infection site was oral mucosal infection in 36 cases (63.16), followed by skin infection in 13 cases (22.81%), and 57 strains of pathogenic bacteria were detected. 38 strains of fungi accounted for 66.67%, 13 strains of Gram-negative bacteria accounted for 22.80, 6 strains of Gram-positive bacteria accounted for 10.53. The first three pathogenic bacteria were Candida albicans, Acinetobacter baumannii and Candida tropicalis, accounting for 50.888.538.775.At old age, they were treated surgically. For 30 days, the risk factors of nosocomial infection in patients with nasopharyngeal carcinoma (NPC) were higher than 2 antibiotics and stage 鈪，

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