重组人粒细胞巨噬细胞集落刺激因子对鼻咽癌急性放射性皮炎的治疗

发布时间：2018-02-28 09:33

本文关键词： 鼻咽肿瘤放射性皮炎放射疗法重组人粒细胞-巨噬细胞集落刺激因子创面愈合　出处：《肿瘤》2015年08期 　论文类型：期刊论文

【摘要】：目的 :探讨重组人粒细胞巨噬细胞集落刺激因子(recombinant human granulocyte macrophage colony-stimulating factor,rh GM-CSF)凝胶治疗鼻咽癌急性放射性皮炎的临床疗效。方法 :将鼻咽癌首程放疗出现≥Ⅱ级急性放射性皮炎的70例患者随机分为A组(rh GM-CSF凝胶治疗组)和B组(聚维酮碘治疗组)各35例,比较2组患者的有效率、创面愈合时间和放疗中断时间。结果 :rh GM-CSF凝胶治疗组急性放射性皮炎的有效率、创面愈合时间和放疗中断时间分别为100%(35/35)、(7.2±1.2)d和(6.6±0.8)d,聚维酮碘治疗组分别为68.6%(24/35)、(11.9±2.3)d和(9.8±1.1)d。rh GM-CSF凝胶治疗组急性放射性皮炎的有效率高于聚维酮碘治疗组,创面愈合时间和放疗中断时间短于聚维酮碘治疗组(P值均0.01)。结论 :rh GM-CSF是一种有效治疗鼻咽癌急性放射性皮炎的方法。
[Abstract]:Objective: to investigate the clinical efficacy of recombinant human granulocyte macrophage colony-stimulating factor-rh GM-CSF gel in the treatment of acute radiation dermatitis of nasopharyngeal carcinoma (NPC). 70 cases of dermatitis were randomly divided into two groups: group A (35 cases) treated with rh GM-CSF gel and group B (35 cases) treated with povidone iodine. The effective rate, wound healing time and radiotherapy interruption time of the two groups were compared. The wound healing time and radiotherapy interruption time were 100 / 35 / 35 / 1 / d and 6.6 卤0.8 / d, respectively. The effective rate of acute radiodermatitis in the povidone iodine treatment group was higher than that in the povidone iodine treatment group, which was 11.9 卤2.3 days and 9.8 卤1.1 days, respectively, in the povidone iodine treatment group, and in the povidone iodine treatment group, the effective rate of acute radiation dermatitis was higher in the treatment group than in the povidone iodine treatment group. The wound healing time and radiotherapy interruption time were lower than that of povidone iodine treatment group (P < 0.01). Conclusion: GM-CSF is an effective method for the treatment of acute radiation dermatitis of nasopharyngeal carcinoma.
【作者单位】：中国人民解放军第一八一医院肿瘤科;中国人民解放军第一八一医院烧伤整形科;
【基金】：桂林市科学研究与技术开发资助项目(编号:20110119-8-2)
【分类号】：R739.63

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