阻塞性睡眠呼吸暂停低通气综合征患者的鼻阻力及nCPAP治疗后的影响

发布时间：2018-03-04 05:00

本文选题：阻塞性睡眠呼吸暂停低通气综合征　切入点：持续气道内正压通气　出处：《实用医学杂志》2014年24期 　论文类型：期刊论文

【摘要】：目的:观察正常成人与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的鼻阻力,比较OSAHS经鼻气道内正压通气(n CPAP)治疗前后鼻阻力的变化,探讨鼻阻力在OSAHS发病中的作用及n CPAP治疗对OSAHS鼻阻力的影响。方法:对11名健康对照者及40例OSAHS患者在完成多导睡眠图(PSG)监测的基础上行鼻阻力测定,OSAHS患者n CPAP治疗3周后复测多导睡眠监测及鼻阻力。结果:OSAHS组鼻阻力为(0.27±0.9)Pa/(cm3·s),高于健康对照组(0.21±0.7)Pa/(cm3·s)(t=-2.048,P0.05),鼻阻力与年龄、体质指数(BMI)、颈围、腰围、呼吸暂停低通气指数(AHI)、最低血氧饱和度(Min SO2)和氧降指数(ODI)无相关关系(P0.05)。中重度OSAHS患者经n CPAP治疗3周后显著改善Min SO2,AHI及ODI(P0.05),而治疗后鼻阻力由(0.27±0.1)Pa/(cm3·s)升高到(0.43±0.3)Pa/(cm3·s)(t=-2.733,P0.05)。结论:鼻阻力增加是OSAHS的发病危险因素之一,而鼻阻力大小与OSAHS的严重程度无关。n CPAP治疗后可导致鼻阻力升高。
[Abstract]:Objective: to observe the nasal resistance of normal adults and patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and compare the changes of nasal resistance before and after OSAHS treatment. To investigate the role of nasal resistance in the pathogenesis of OSAHS and the effect of n CPAP therapy on OSAHS nasal resistance. Methods: 11 healthy controls and 40 OSAHS patients were examined for n CPAP on the basis of polysomnography monitoring. Results after 3 weeks of treatment, the nasal resistance was 0.27 卤0.9A / r / cm ~ 3 路sm ~ (-1), which was higher than that in the healthy control group (0.21 卤0.7), and was higher than that in the healthy control group (0.21 卤0.7) (P < 0.05), and the nasal resistance and age were higher than those in the healthy control group (P = 0.21 卤0.7 ~ (-1) / m ~ (3) 路s ~ (-1) ~ (-2.048)). Body mass index (BMI), neck circumference, waist circumference, There was no correlation between apnea hypopnea index (OSAHS), minimum oxygen saturation (MOO _ 2) and oxygen drop index (ODI). After 3 weeks of treatment with n CPAP, patients with moderate and severe OSAHS significantly improved Min SO2AHI and IODP0.05, while nasal resistance increased from 0.27 卤0.1Paccm3 路s to 0.43 卤0.3Pm3-2.733P0.05. conclusion:. Increased resistance is one of the risk factors for OSAHS. However, the nasal resistance was not related to the severity of OSAHS. N CPAP could increase the nasal resistance after treatment.
【作者单位】：广州医科大学附属一第医院呼吸疾病国家重点实验室广州呼吸疾病研究所耳鼻喉科;广州医科大学附属一第医院呼吸疾病国家重点实验室广州呼吸疾病研究所呼吸内科;
【基金】：广东省高等学校科技创新团队项目(编号:06CXTD008)
【分类号】：R766

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