532nm绿激光格栅样光凝联合球内注药治疗糖尿病视网膜病变黄斑水肿

发布时间：2018-03-05 11:19

本文选题：糖尿病视网膜病变　切入点：黄斑水肿　出处：《眼科新进展》2014年08期 　论文类型：期刊论文

【摘要】：目的观察532 nm绿激光格栅样光凝联合球内注药治疗糖尿病视网膜病变(diabetic retinopathy,DR)黄斑水肿的临床疗效。方法选择2011年1月至2012年12月我院收治的DR黄斑水肿患者40例(80眼),随机分为治疗组和对照组,每组20例,对照组给予单纯532 nm绿激光格栅样光凝术,治疗组在532 nm绿激光格栅样光凝术前给予球内注射Avastin(美国Genentech公司)。随访期末采用眼底镜及FFA观察患者眼底改变情况,采用国际标准视力表检查患者治疗前后视力,同时使用光学相干断层扫描仪检查患者治疗前后的黄斑区视网膜厚度。结果治疗组治愈22眼,显效16眼,无效2眼,总有效率为95.0%;对照组治愈17眼,显效16眼,无效7眼,总有效率为82.5%;经统计学分析,两组患者的总有效率差异有统计学意义(P0.05),治疗组疗效好于对照组。治疗前视力比较,两组差异无统计学意义(P0.05);与治疗前视力相比,治疗后视力均显著提高(均为P0.05);治疗后视力组间比较,治疗组视力好于对照组(P0.05)。治疗组和对照组治疗前黄斑区视网膜厚度分别为(425.44±38.23)μm、(437.66±36.12)μm,两组间差异无统计学意义(P0.05);治疗后黄斑区视网膜厚度分别为(165.28±25.64)μm、(275.78±42.14)μm,较治疗前均降低(均为P0.05),且治疗组低于对照组(P0.05)。结论相对于单纯激光光凝术,532 nm绿激光格栅样光凝联合球内注药治疗DR更加安全有效,术后视力恢复更快,黄斑水肿吸收更好。
[Abstract]:Objective to observe the clinical effect of 532nm green laser grid photocoagulation combined with intrabulbar injection in the treatment of diabetic retinopathy (DRR) macular edema. Methods from January 2011 to December 2012, 40 patients with Dr macular edema were treated in our hospital from January 2011 to December 2012. The eyes were randomly divided into two groups: treatment group and control group. Twenty patients in each group were treated with simple 532nm green laser grid photocoagulation, and the treatment group were treated with intrabulbar injection of Avastin before 532nm green laser grid photocoagulation (Genentech Company, USA). Fundus microscopy and FFA were used to observe the fundus changes of the patients at the end of follow-up. The visual acuity of the patients before and after treatment was examined by international standard visual acuity meter, and the retinal thickness of macular area was examined by optical coherence tomography. Results 22 eyes were cured, 16 eyes were effective and 2 eyes were ineffective in the treatment group. The total effective rate was 95.0; in the control group, 17 eyes were cured, 16 eyes were markedly effective, 7 eyes were ineffective, and the total effective rate was 82.5. By statistical analysis, the total effective rate of the two groups was significantly different (P 0.05). The curative effect of the treatment group was better than that of the control group. There was no significant difference between the two groups (P 0.05), the visual acuity after treatment was significantly improved compared with that before treatment (P 0.05), and the visual acuity after treatment was significantly higher than that before treatment (P 0.05). The retinal thickness of macular area in treatment group and control group was 425.44 卤38.23 渭 m and 437.66 卤36.12 渭 m, respectively. There was no significant difference between the two groups in retinal thickness of macular area (165.28 卤25.64) 渭 m, 275.78 卤42.14 渭 m after treatment. Conclusion compared with simple laser photocoagulation with 532nm green laser grid photocoagulation combined with intraball injection, the treatment group is more safe and effective in the treatment of Dr than that in the control group. Postoperative visual acuity recovered faster and macular edema was absorbed better.
【作者单位】：莱芜市人民医院眼科;莱芜市人民医院内分泌科;
【分类号】：R587.2;R774

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