结晶样视网膜变性患者脉络膜和视网膜血流的异常变化

发布时间：2018-03-09 11:42

本文选题：结晶样视网膜变性　切入点：彩色多普勒血流显像　出处：《眼科新进展》2014年06期 　论文类型：期刊论文

【摘要】：目的研究结晶样视网膜变性(crystalline retinal degeneration,CRD)患者眼动脉(OA)、视网膜中央动脉(CRA)和睫状后动脉(PCA)血流参数变化特点。方法应用彩色多普勒血流成像技术检测35例(35眼)临床诊断为CRD的患者。测定OA、CRA及PCA的收缩期峰速(PSV)、舒张末期流速(EDV)、时间平均最大流速(TAMV)、脉动指数(PI)和阻力指数(RI)。所得定量数据采用单样本t检验,对CRD组与正常组的各项参数进行比较。结果 CRD患者中OA的PI(1.80±0.55)较正常组(2.02±0.71)明显降低(t=-2.460,P=0.019)。CRD患者CRA的PSV(6.73±1.77)cm·s-1较正常组(10.82±2.97)cm·s-1明显降低(t=-13.649,P=0.000),EDV(2.10±0.41)cm·s-1较正常组(3.28±1.11)cm·s-1明显降低(t=-17.009,P=0.000),TAMV(3.60±1.00)cm·s-1较正常组(5.50±2.06)cm·s-1明显降低(t=-11.365,P=0.000),PI(0.67±0.09)较正常组(1.48±0.49)明显降低(t=-5.030,P=0.000)和RI(0.67±0.09)较正常组(0.71±0.08)明显降低(t=-2.774,P=0.009)。CRD患者PCA的PSV(6.64±1.76)cm·s-1较正常组(11.61±3.41)cm·s-1明显降低(t=-16.897,P=0.000),EDV(2.37±0.69)cm·s-1较正常组(3.34±1.25)cm·s-1明显降低(t=-8.327,P=0.000),TAMV(3.60±1.16)cm·s-1较正常组(5.83±1.91)cm·s-1明显降低(t=-11.374,P=0.000),PI(1.18±0.32)较正常组(1.49±0.43)明显降低(t=-5.690,P=0.000)和RI(0.64±0.82)较正常组(0.70±0.09)明显降低(t=-4.650,P=0.000)。结论 CRD患者OA、CRA和PCA血流参数异常提示眼部的血液供应和CRD病理过程存在相关性。
[Abstract]:Objective to study the blood flow parameters of central retinal artery (CA) and posterior ciliary artery (PCA) in patients with crystalline retinal degeneration.Methods Color Doppler flow imaging (CDFI) was used to detect 35 cases (35 eyes). The peak systolic velocities of CRD and PCA, end diastolic velocity (EDV), mean mean maximum flow velocity (TAMV), pulsation index (Pi) and resistance index (RI) were measured by single sample t test. Results the PI(1.80 卤0.55 of OA in CRD group was significantly lower than that in normal group (2.02 卤0.71). The PSV(6.73 卤1.77 cm 路s-1 of CRA in CRD group was significantly lower than that in normal group (10.82 卤2.97cm 路s-1 vs 10.82 卤2.97cm 路s-1 vs 5.50 卤0.49cm 路s-1 vs 3.28 卤1.11cm 路s-1 vs 3.28 卤1.11cm 路s-1). The PSV(6.64 卤1.76cm 路s -1 in the patients with low t ~ (1) -11.365m ~ (0.000) ~ (0.67 卤0.09)) was significantly lower than that in the normal group (1.48 卤0.49)) and the RI(0.67 卤0.09) was significantly lower than that in the normal group (3.34 卤1.25cm 路s ~ (-1)). The PSV(6.64 卤1.76cm 路s ~ (-1) was significantly lower than that in the normal group (11.61 卤3.41 卤3.41 cm 路s ~ (-1)) compared with the normal group (2.37 卤0.69) cm 路s ~ (-1) and (3.34 卤1.25 cm 路s ~ (-1)). RI(0.64 卤0.82) was significantly lower than that of normal group (0.70 卤0.09). Conclusion the abnormal blood flow parameters of CRD patients suggest that there is a correlation between the blood supply of the eyes and the pathological process of CRD.
【作者单位】：首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室;
【基金】：国家自然科学基金资助(编号:81271046)~~
【分类号】：R774.13

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