慢性鼻窦炎患者鼻内镜术后中药液冲洗术腔临床疗效及安全性循证医学研究

发布时间：2018-03-09 18:02

本文选题：系统评价　切入点：慢性鼻窦炎　出处：《成都中医药大学》2010年硕士论文　论文类型：学位论文

【摘要】：目的评价中药液冲洗治疗对慢性鼻窦炎患者鼻内镜术后术腔恢复的临床疗效和安全性。方法通过计算机检索电子数据库和手工检索重要期刊的方式,收集慢性鼻窦炎鼻内镜术后使用中药液冲洗治疗的随机对照试验(RCT)文献,按纳入及排除标准筛选文献、评价研究质量、提取文献有效数据,并采用RevMan 4.2.10进行统计分析。结果3个亚组共纳入32篇中文文献,经过以疗效为主要终点指标和以术后症状改善评级、黏膜形态、鼻腔纤毛运动速率、术腔清洁时间、术腔上皮化时间、鼻腔免疫功能指标、不良反应等次要结局指标的meta分析后,结果提示鼻内镜术后使用中药液冲洗术腔的疗效优于单纯生理盐水或西药液冲洗的可能性较高。安全性方面,由于本文中纳入的关于不良反应的文献报道较少,在现有研究结果下尚不能证明中药液冲洗术腔治疗方法存在优于单纯生理盐水或西药液冲洗的可能。结论在慢性鼻窦炎鼻内镜术后的治疗中,采用中药液冲洗治疗可提高临床疗效、加快愈合时间,不良反应发生率较小,但由于纳入试验方法学质量普遍较低,评价指标合理的文献较少,尚需进一步开展设计科学、指标合理的随机对照试验。
[Abstract]:Objective to evaluate the clinical efficacy and safety of Chinese medicine irrigation in patients with chronic sinusitis after endoscopic sinus surgery. Methods by means of computer searching electronic database and manual retrieval of important journals, the literature of RCTs of the patients with chronic sinusitis treated with traditional Chinese medicine after endoscopic surgery was collected, and the literature was screened according to the inclusion and exclusion criteria. The quality of the study was evaluated and the effective data were extracted and analyzed by RevMan 4.2.10. Results 32 articles of Chinese literature were included in the three subgroups. The main endpoints were curative effect and the improvement of postoperative symptoms, mucosal morphology, ciliary movement rate, cleaning time and epithelialization time. After meta analysis of the secondary outcome indexes such as nasal immune function and adverse reactions, the results showed that the efficacy of using Chinese medicine to wash the cavity after nasal endoscopy was better than that of saline or western medicine. Because there are few reports on adverse reactions in this paper, it is not possible to prove that the Chinese medicine solution washing method is superior to the normal saline or western medicine solution washing method under the existing research results. Conclusion in the treatment of chronic sinusitis after endoscopic sinus surgery, the use of Chinese medicine liquid washing therapy can improve the clinical efficacy, accelerate the healing time, and the incidence of adverse reactions is small, but the quality of the methodology is generally low. There are few literatures on reasonable evaluation index, so it is necessary to further develop the randomized controlled trial with scientific design and reasonable index.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R765.9

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