螺旋断层放疗联合顺铂治疗局部晚期鼻咽癌的临床研究

发布时间：2018-03-10 08:05

本文选题：鼻咽肿瘤　切入点：晚期　出处：《重庆医学》2014年06期 　论文类型：期刊论文

【摘要】：目的观察螺旋断层放疗(HT)联合顺铂方案(HT-P)同步治疗局部晚期鼻咽癌的近期疗效及急性不良反应,并与三维适行放疗(3DCRT)联合顺铂方案(3DCRT-P)作对照。方法收集2011年7月至2012年7月局部晚期鼻咽癌患者73例,分为HT-P组33例,3DCRT-P组40例;选取患者的CT图像,在Pinnacle 9.0计划统一勾画靶区及正常器官后,分别输入HT及3DCRT计划系统,鼻咽癌原发病灶(pGTVnx)给予70~74Gy/30~33f,转移性淋巴结(pGTVnd)给予64~70Gy/30~33f,亚临床病灶区(PTV1)给予60~64Gy/30~33f,预防照射区(PTV2)给予50~56Gy/30~33f。均同步给予顺铂化疗,顺铂80mg/m2第1、22、43天。统计放疗开始第1天至放疗结束后1个月的急性不良反应,并在放疗结束后1个月复查,评价疗效。结果 HTP组和3DCRT-P组的完全缓解率(CRR),有效率(RR)、局控率(LCR)分别为42.4%和42.5%、97%和97.5%、97.0%和100%,两组CRR、RR、LCR差异均无统计学意义(P0.05)。HT-P组的放射性涎腺反应明显低于3DCRT-P组(P0.05)。结论HT-P治疗局部晚期鼻咽癌的近期疗效与3DCRT-P相似,但急性放射性涎腺反应低于3DCRT-P。
[Abstract]:Objective to observe the short-term efficacy and acute adverse reaction of spiral tomography radiotherapy (HTT) combined with cisplatin regimen (Cisplatin) in the treatment of locally advanced nasopharyngeal carcinoma (NPC). Methods from July 2011 to July 2012, 73 patients with locally advanced nasopharyngeal carcinoma were divided into HT-P group (n = 33) and 3DCRT-P group (n = 40). After the Pinnacle 9.0 project outlines the target area and the normal organs, the HT and 3DCRT planning systems are input, respectively. The primary lesion of nasopharyngeal carcinoma (pGTVnx) was given 70 ~ 74 Gy / 30 ~ 33 f, metastatic lymph node pGTVnd) 64 ~ 70 Gy / 30 ~ 33 f, subclinical focus area ~ (PTV1) 60 ~ 64 Gy / 30 ~ 33 f, prevention area ~ (PTV _ 2) 50 ~ 56 Gy / 30 ~ 33 f. All patients were given cisplatin chemotherapy at the same time. Cisplatin 80 mg / m2, day 1, 22 and 43. The acute adverse reactions from the first day of radiotherapy to the end of 1 month after radiotherapy were counted and reexamined 1 month after radiotherapy. Results the complete remission rate and the effective rate of HTP and 3DCRT-P groups were 42.4% and 42.5%, 97.50% and 100, respectively. Conclusion the radioactivity of salivary gland in HTP group and 3DCRT-P group was significantly lower than that in 3DCRT-P group. Conclusion the radioactivity of salivary gland in HTP group and 3DCRT-P group is significantly lower than that in 3DCRT-P group. The short-term curative effect of local advanced nasopharyngeal carcinoma is similar to that of 3DCRT-P. But the acute radioactivity of salivary gland was lower than that of 3DCRT-P.
【作者单位】：广州军区广州总医院肿瘤科;
【基金】：广东省科技计划项目(2010B031600266,2012B031800181) 广东省医学科研基金(A2012442)
【分类号】：R739.63

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