阻塞性睡眠呼吸暂停低通气综合征对冠心病患者造影剂肾病发病率的影响

发布时间：2018-03-10 17:29

本文选题：阻塞性睡眠呼吸暂停低通气综合征　切入点：冠心病　出处：《中国动脉硬化杂志》2014年12期 　论文类型：期刊论文

【摘要】：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对冠心病(CHD)患者造影剂肾病(CIN)发病率的影响。方法根据冠状动脉造影及多导睡眠监测的结果,将研究对象分为CHD无OSAHS组48例、CHD并OSAHS组62例,比较两组冠状动脉造影前后血清肌酐的变化及造影剂肾病的发病率。结果两组血清肌酐水平在冠状动脉造影前48 h内差异无统计学意义(t=-0.733,P=0.465),冠状动脉造影和(或)经皮冠状动脉介入术后第1天、第3天CHD并OSAHS组血清肌酐水平高于CHD无OSAHS组,差异有统计学意义(t=-2.486,P=0.014;t=-2.921,P=0.004)。在纳入的研究对象中,18例发生CIN,总体CIN发生率为16.36%,其中CHD无OSAHS组4例,CIN发生率为8.33%,CHD并OSAHS组14例,CIN发生率为22.58%,两组患者CIN发病率差异具有统计学意义(χ2=4.013,P=0.045)。结论阻塞性睡眠呼吸暂停低通气综合征是冠心病患者造影剂肾病发生的一个相关风险因素。
[Abstract]:Objective to investigate the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) on the incidence of contrast-agent nephropathy (CINs) in patients with coronary heart disease (CHD). Methods according to the results of coronary angiography and polysomnography, The subjects were divided into CHD without OSAHS group (n = 48) and OSAHS group (n = 62). The changes of serum creatinine before and after coronary angiography and the incidence of contrast nephropathy were compared between the two groups. Results there was no significant difference in serum creatinine levels between the two groups within 48 hours before coronary angiography. The first day after percutaneous coronary intervention, On the 3rd day, the serum creatinine level in CHD and OSAHS group was higher than that in CHD without OSAHS group. The difference was statistically significant (n = 18), and the overall incidence rate of CIN was 16.3636. The incidence of cin in CHD without OSAHS group was 8.33%, and 14 cases in OSAHS group was 22.58%. There was a statistical difference between the two groups in the incidence of CIN. Conclusion obstructive sleep apnea hypopnea syndrome is a risk factor for contrast agent nephropathy in patients with coronary heart disease.
【作者单位】：郑州大学第一附属医院心内科;郑州大学第二附属医院心内科;
【分类号】：R766

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