头孢呋辛与阿奇霉素治疗慢性鼻窦炎的临床疗效对比研究

发布时间：2018-03-14 04:06

本文选题：头孢呋辛　切入点：阿奇霉素　出处：《中华医院感染学杂志》2014年05期 　论文类型：期刊论文

【摘要】：目的研究头孢呋辛与阿奇霉素治疗慢性鼻窦炎的临床疗效,以期指导临床合理用药。方法选取临床186例慢性鼻窦炎患者,均于围手术期应用抗菌药物,术前使用3~7d,术后最长使用6个月,术后一周以内均静脉滴注抗菌药物;186例患者随机分为两组,阿奇霉素组应用阿奇霉素0.5g每日1次,头孢呋辛组应用头孢呋辛1.5g每日2次;与治疗后2、4、6周对两组治疗效果进行比较分析,采用SPSS 13.0软件进行数据处理,资料比较采用χ2检验,计量资料间比较采用t检验,P0.05为差异有统计学意义。结果治疗两周后总有效率阿奇霉素组20.7%、头孢呋辛组23.4%,两组患者的总有效率差异无统计学意义;治疗4周后总有效率阿奇霉素组30.4%、头孢呋辛组56.4%,治疗6周后总有效率阿奇霉素组51.1%、头孢呋辛组72.3%,两组患者的治疗4、6周总有效率差异有统计学意义(P0.05),且头孢呋辛组的有效率明显高于阿奇霉素组。结论头孢呋辛用于治疗慢性鼻窦炎的临床疗效优于阿奇霉素,头孢呋辛应作为首选抗菌药物治疗慢性鼻窦炎,在临床进行推广。
[Abstract]:Objective to study the clinical curative effect of cefuroxime and azithromycin in the treatment of chronic sinusitis, in order to guide the clinical rational use of drugs. Methods 186 cases of patients with chronic sinusitis, in the perioperative application of antibacterial drugs, the use of 3~7d before surgery, after surgery the longest 6 months after operation within one week were intravenous antibiotics; 186 patients were randomly divided into two groups, 0.5g group used azithromycin azithromycin 1 times daily, cefuroxime group application cefuroxime 1.5g 2 times daily; comparative analysis and treatment of 2,4,6 weeks after the treatment effects of the two groups, using SPSS 13 software for data processing, data were compared with the 2 test, comparison of measurement data using t test. P0.05 the difference was statistically significant. Results after two weeks of treatment, the total effective rate of azithromycin cefuroxime group 20.7%, group 23.4%, two groups of the total efficiency of the difference was not statistically significant; after 4 weeks of treatment the total The efficiency of the azithromycin group 30.4%, cefuroxime group 56.4%, after 6 weeks of treatment, the total efficiency of 51.1% in the azithromycin group, cefuroxime group 72.3%, treatment group two patients 4,6 weeks total efficiency difference was statistically significant (P0.05), and cefuroxime group was significantly higher than the azithromycin group. Conclusion azithromycin is better than cefuroxime for clinical curative effect of the treatment of chronic sinusitis cefuroxime, should be the first choice of antibiotics in the treatment of chronic sinusitis in clinical practice.

【作者单位】：中国航天科工集团731医院耳鼻喉科;
【基金】：十一五国家科技支撑计划基金资助项目(2006BAI104A01) 北京市科技计划重大基金项目(H020920010491)
【分类号】：R765.41

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