中重度持续性变应性鼻炎患者鼻与下气道炎症特征分析

发布时间：2018-03-14 17:49

本文选题：中重度持续性　切入点：变应性鼻炎　出处：《南京大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：通过鼻激发试验(Nasal Provocation Test, NPT)、支气管激发试验(Bronchial Provocation Test, BPT)及鼻灌洗、诱导痰嗜酸性粒细胞(eosinophils, EOS)计数,分析中重度持续性变应性鼻炎(Allergic Rhinitis, AR)患者鼻与下气道炎症特征。方法：对80名正常对照组、101名中重度持续性AR患者行NPT、BPT及鼻灌洗、诱导痰EOS计数。结果： 1、AR组基础肺功能(FVC、FEV1)与对照组相比,差异无统计学意义(p0.05)； 2、AR组NPT阳性率为75.2%(76/101),与对照组42.5%(34/80)相比,差异有统计学意义(x2=20.081, p=0.000); 3、AR组BPT阳性率为14.9%(15/101),与对照组2.5%(2/80)相比,差异有统计学意义(x2=8.003,p0.05), 4、鼻灌洗EOS数量为22.09±85.3,对照组为0.41±1.27,差异有统计学意义(t=-10.469,p0.01)； 5、AR组诱导痰EOS数量为11.02±18.22,对照组为(1.62±2.88)相比,差异有统计学意义(t=-5.648,p0.01), 6、AR组鼻与下气道EOS水平存在相关性(r=0.31,p0.01)。结论： 1、中重度持续性AR患者基础肺功能较正常人无明显改变； 2、AR患者鼻与下气道呈现明显的高反应性； 3、AR患者鼻与下气道存在显著增高的EOS浸润； 4、AR以鼻与下气道EOS浸润及反应性增高为炎症特征； 5、AR上下气道炎症具有一致性； 6、建议AR患者检查下气道炎症状况,有异常者应早期进行下气道干预。
[Abstract]:Objective: to analyze nasal and inferior airway inflammation in patients with moderate and severe persistent allergic rhinitis (ARs) by nasal stimulation test, nasal stimulation test, bronchial Provocation test and nasal lavage, and count of eosinophils (EOS) in induced sputum eosinophilus (eosinophilus). Methods: 101 patients with moderate or severe persistent AR were treated with NPT, nasal lavage and induced sputum EOS count. Results:. (1) compared with the control group, there was no significant difference in the basic lung function between the AR group and the control group (P 0.05). 2the positive rate of NPT in AR group was 75.2% / 101%, which was significantly higher than that in control group (42.5%) (20.081%) and 0.000% (P < 0.05). 3The positive rate of BPT in AR group was 14. 9% / 101%, which was significantly higher than that in control group (2. 5% / 80). (4) the number of EOS in nasal lavage was 22.09 卤85.3, that in control group was 0.41 卤1.27, the difference was statistically significant (P < 0.01). The number of induced sputum EOS was 11.02 卤18.22 in AR group and 1.62 卤2.88 in control group. There was a correlation between the EOS level of nasal and lower airway in 6patients with AR. Conclusion:. 1. There was no significant change in basic pulmonary function in moderate and severe persistent AR patients compared with normal controls. 2the nasal and inferior airway showed obvious hyperresponsiveness in patients with AR. 3There were significantly increased EOS infiltration in nose and lower airway in patients with AR. 4AR was characterized by EOS infiltration and increased reactivity in the nasal and lower airway. 5the inflammation of upper and lower airway of AR is consistent; 6. It is suggested that AR patients should check for lower airway inflammation, and early intervention should be carried out in patients with abnormal airway.
【学位授予单位】：南京大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R765.21

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