早期干预在减缓鼻咽癌放疗后分泌性中耳炎中的作用

发布时间：2018-03-15 20:17

本文选题：鼻咽癌　切入点：分泌性中耳炎　出处：《中华耳科学杂志》2014年04期 　论文类型：期刊论文

【摘要】：目的探讨鼻咽癌患者放疗早期经鼓室注入曲安奈德及氨溴索溶液在减缓放疗后分泌性中耳炎中的作用。方法收集在放疗前无分泌性中耳炎症状的鼻咽癌患者40例,共有64耳在放射野内,分为实验组和对照组各32耳。实验组于放疗量达30Gy开始每周鼓室注射曲安奈德及氨溴索混合液,对照组不进行任何预防性处理,直到放疗结束,两组病人均观察至放疗结束后6个月,比较分析两组病人在放疗结束,放疗后第3个月末及第6个月末患分泌性中耳炎的概率。结果放疗结束时实验组1人1耳出现分泌性中耳炎(1/32),对照组有4人6耳出现分泌性中耳炎(6/32),两者差异有统计学意义(X2=18.19,p0.01)。放疗后第3个月末实验组有2人2耳出现分泌性中耳炎(2/32),对照组中有6人共9耳出现分泌性中耳炎(9/32),两者差异有统计学意义(X2=20.75,p0.01)。第6个月末时实验组有4人共6耳出现分泌性中耳炎(6/32),对照组共有13人共18耳出现分泌性中耳炎(18/32),两者差异有统计学意义(X2=30.47,p0.01)。结论在鼻咽癌放疗早期经鼓室注入曲安奈德及氨溴索,能减缓鼻咽癌患者放疗后分泌性中耳炎进程。
[Abstract]:Objective to investigate the effect of tympanic injection of triamcinolone acetonide and ambroxol solution in the early stage of radiotherapy for nasopharyngeal carcinoma (NPC). Methods Forty patients with nasopharyngeal carcinoma without secretory otitis media symptoms before radiotherapy were collected. A total of 64 ears in the radiation field were divided into experimental group (32 ears) and control group (32 ears). The experimental group received triamcinolone acetonide and ambroxol in the tympanic cavity weekly at a dose of 30 Gy, and the control group did not undergo any preventive treatment until the end of radiotherapy. The patients in both groups were observed until 6 months after the end of radiotherapy, and the two groups were compared and analyzed at the end of radiotherapy. The probability of secretory otitis media at the third and sixth month after radiotherapy. Results at the end of radiotherapy, 1 person in the experimental group had 1 / 32 ears of secretory otitis media and 6 ears in the control group had 6 / 32 ears of secretory otitis media. The difference between the two groups was significant. At the end of the third month after radiotherapy, there were 2 cases of secretory otitis media in 2 ears in the experimental group and 9 / 32 in 9 ears in the control group. The difference between the two groups was statistically significant. At the end of the sixth month, the experimental group developed secretory otitis media with 20. 75% P 0. 01. There were 6 ears with secretory otitis media in 4 patients and 18 ears with 18 ears with secretory otitis media in the control group. The difference was statistically significant. Conclusion Triamcinolone acetonide and ambroxol were injected into the tympanic chamber of nasopharyngeal carcinoma at the early stage of radiotherapy, and ambroxol and triambroxol were injected into the tympanic chamber. It can slow down the progress of secretory otitis media after radiotherapy in patients with nasopharyngeal carcinoma.
【作者单位】：东南大学附属江阴医院耳鼻咽喉科;
【分类号】：R739.63

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