巴曲酶治疗突发性耳聋效果及安全性的系统评价

发布时间：2018-03-17 15:42

本文选题：突发性耳聋　切入点：巴曲酶　出处：《新疆医科大学》2010年硕士论文　论文类型：学位论文

【摘要】：目的:系统评价巴曲酶治疗突发性耳聋的效果及安全性。方法:按照Cochrane系统评价制作方法,计算机检索Medline(1980-2009.9),Embase(1980-2009.9),中国生物医学文献数据库(1980-2009.9)CNKI(1980-2009.9),Cochrane协作网耳鼻喉疾病组(2009年3期);并手工检索相关领域文献,收集所有相关随机对照试验(RCT)和半随机对照试验(qasy-RCT),评价纳入研究的方法学质量,提取资料,并用Cochrane协作网提供的RevMan4.2软件对数据进行Meta分析。结果:共纳入3篇随机对照试验,包括242例患者。Meta分析结果显示,在使用药物治疗突发性耳聋的患者中,巴曲酶与常规药物在治疗突发性耳聋的治愈率[RR=1.79,95%CI(1.16-2.74),P=0.008]、无效率[RR=0.4,95%CI(0.25-0.64),P=0.0001]方面有统计学意义。在显著有效率[RR=1.41,95%CI(0.83-2.40),P=0.2]、有效率[RR=1.03,95%CI(0.71-1.52),P=0.86]方面无统计学意义,与疏血通相比在各结局指标中均无统计学意义。结论:巴曲酶与常规药物在治疗突发性耳聋的患者中显著有效率、有效率无差异,但与常规药物相比较,巴曲酶能提高患者的治愈率,降低患者的无效率,巴曲酶与疏血通的治疗效果无明显差异。由于本系统评价纳入的研究较少,临床研究质量普遍偏低,且缺乏安全性资料,对巴曲酶治疗突发性耳聋的有效性和安全性上不能得出肯定结论,有待于高质量、大样本、多中心的双盲随机对照试验结果证实,以增强论证强度。
[Abstract]:Objective: to evaluate the efficacy and safety of batroxobin in the treatment of sudden deafness. Computer search of Medline #en0# (1980-2009.9) Embase 1980-2009, Chinese Biomedical Literature Database 1980-2009.9CNKIN 1980-2009.9 Cochrane Cooperative Network for Otolaryngology (issue 3, 2009), and manual retrieval of related literature. All relevant randomized controlled trials (RCTs) and semi-randomized controlled trials were collected to evaluate the quality of methodology included in the study, to extract data, and to analyze the data by Meta using RevMan4.2 software provided by the Cochrane Cooperative Network. Results: three randomized controlled trials were conducted. The results of the Meta-analysis, including 242 patients, showed that in patients with sudden deafness treated with drugs, Batroxobin and conventional drugs have statistical significance in the cure rate of sudden deafness [RRRN 1.79-95 CIQ 1.16-2.74 P0. 008], the inefficiency rate [RRN 0.495 CI 0.25-0.64 P0. 0001], but there is no statistical significance in the significant effective rate [RR1.4195CI0.83-2.40P0. 2], but there is no statistical significance in the effective rate [RR1. 0395CII 1. 735 CIQ 1. 52P 0. 86], and there is no statistical significance in the treatment of sudden deafness with Batroxobin and conventional drugs. The results show that there is no significant difference in the cure rate between Batroxobin and conventional drugs in the treatment of sudden deafness. Compared with Shuxuetong, there was no statistical significance in each outcome index. Conclusion: Batroxobin and conventional drugs have significant effective rate in the treatment of sudden deafness, but there is no difference in effective rate, but it is compared with conventional drugs. Batroxobin can improve the cure rate and reduce the inefficiency of patients. There is no significant difference in the therapeutic effect between batroxobin and Shuxuetong. The efficacy and safety of batroxobin in the treatment of sudden deafness can not be confirmed. The results of double-blind randomized controlled trials with high quality, large sample and multiple centers are needed to enhance the intensity of demonstration.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R764

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