血清半胱氨酸白三烯对儿童阻塞性睡眠呼吸暂停低通气综合征的诊断价值及意义

发布时间：2018-03-19 19:21

  本文选题：睡眠呼吸暂停低通气综合征　切入点：阻塞性　出处：《新疆医科大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患儿血清半胱氨酸白三烯（CysLTs）水平的变化及意义，为临床诊断和治疗OSAHS提供科学依据。方法：选择OSAHS患儿41名（OSAHS组），按AHI水平将OSAHS组分为轻、中、重三组，对照组34名，所有受试者均接受多导睡眠仪监测，采用竞争酶联免疫分析法（ELASA）测定各组血清CysLTs水平，并将OSAHS组的血清CysLTs与各睡眠呼吸参数进行相关分析。结果：（1）OSAHS组血清CysLTs水平（683.102±89.825）pg/mL高于对照组（461.985±84.951）pg/mL，差异有统计学意义（P＜0.05）。（2）OSAHS组患儿血清CysLTs水平与呼吸暂停低通气指数（AHI）、最长呼吸暂停时间（LAT）、最长低通气时间（LHT）呈正相关（r值分别为0.417、0.422、0.208，P均＜0.05），与最低血氧饱和度（LSaO2）水平、平均血氧饱和度（MSaO2）呈负相关（r值分别为-0.192、-0.255，P均0.05），（3）重度OSAHS组患儿血清CysLTs水平（773.118±92.015）pg/mL高于中度OSAHS组患儿血清CysLTs水平（712.144±41.331）pg/mL，亦明显高于轻度OSAHS组患儿血清CysLTs水平（642.206±77.250）pg/mL，各组间有明显差异（P均＜0.05）。（4）当患儿血清CysLTs水平为560.872pg/mL时为最佳临界点，，此临界点的灵敏度（92.7%）和特异度（94.1%）均最高，误诊率和漏诊率较小，诊断符合率为93.3%。结论：OSAHS组血清CysLTs水平高于对照组，CysLTs水平与OSAHS的严重程度密切相关。不同民族OSAHS患儿血清CysLTs水平有差异，血清CysLTs水平可能作为一个血清标志物来初步筛查可疑OSAHS患儿。
[Abstract]:Objective: to investigate the changes and significance of serum cysteine leukotriene (CysLTs) levels in children with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: 41 children with OSAHS were divided into three groups according to the level of AHI, mild, moderate and severe, and 34 in control group. All subjects were monitored by polysomnography. The level of serum CysLTs was determined by competitive enzyme linked immunosorbent assay (Elisa). Results the serum CysLTs level in the OSAHS group was 683.102 卤89.825 渭 g / mL higher than that in the control group (461.985 卤84.951g / mL). The difference was statistically significant (P < 0.05). 2. The serum CysLTs level and the apnea hypopnea index (AHI) in the OSAHS group were significantly higher than those in the control group (P < 0.05). There was a positive correlation between LHT and LHT (0.417 卤0.422 卤0.208, P < 0.05), and the lowest oxygen saturation (LSaO _ 2), and the lowest oxygen saturation (LSaO _ 2). Serum CysLTs level in severe OSAHS group was 773.118 卤92.015 PG / mL higher than that in moderate OSAHS group (712.144 卤41.331pgmL) and significantly higher than that in mild OSAHS group (642.206 卤77.250 PG / mL). When the serum CysLTs level was 560.872pg / mL, it was the best critical point. The sensitivity and specificity of this critical point were the highest, and the misdiagnosis rate and missed diagnosis rate were small. Conclusion the level of serum CysLTs is significantly higher in the control group than that in the control group, and it is closely related to the severity of OSAHS. There are differences in serum CysLTs levels among the children with OSAHS from different nationalities. Serum CysLTs level may be used as a serum marker to screen suspected OSAHS children.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R766

【参考文献】

相关期刊论文 前10条

1 刘大波,钟建文;小儿睡眠呼吸暂停综合征围手术期处理[J];中国当代儿科杂志;2002年05期

2 徐保平,申昆玲,张亚梅,安嘉清;手术治疗腺样体肥大儿童阻塞性睡眠呼吸暂停综合征[J];中国当代儿科杂志;2004年02期

3 吴婕翎;陈爱欢;彭秋莹;陈荣昌;钟南山;;哮喘儿童吸入糖皮质激素疗效与白三烯水平的相关性探讨[J];中国当代儿科杂志;2009年06期

4 陈军;多力坤;;超敏C-反应蛋白和胰岛素敏感指数在儿童阻塞性睡眠呼吸暂停综合征中的变化[J];中国当代儿科杂志;2011年03期

5 赵德育;;白三烯受体拮抗剂在儿童支气管哮喘治疗中的地位[J];儿科药学杂志;2007年01期

6 黄丽萍,方凤;白三烯与支气管哮喘[J];国外医学.呼吸系统分册;2005年09期

7 梁大华;刘建红;韦彩周;王武;雷志坚;;阻塞性睡眠呼吸暂停综合征的白细胞抗原基因测定[J];广西医学;2008年04期

8 江成琼;;阻塞性睡眠呼吸暂停低通气综合征患者围手术期护理[J];西南军医;2009年05期

9 张晓英;徐佩茹;多力坤;李西华;;动态心电图对儿童阻塞性睡眠呼吸暂停综合征的诊断价值[J];临床儿科杂志;2006年03期

10 余洋;梅伟;崔永华;;S-B评分量表对OSAHS预测作用的初步评价[J];临床耳鼻咽喉头颈外科杂志;2012年06期

本文编号：1635649