早期喉癌手术切缘组织p53和c-myc表达与局部复发的关系

发布时间：2018-03-20 17:12

本文选题：喉肿瘤　切入点：p　出处：《诊断病理学杂志》2014年01期 　论文类型：期刊论文

【摘要】：目的检测p53和c-myc蛋白在早期喉癌手术切缘组织中的表达及其与肿瘤局部复发的关系。方法选择2004—2010年间唐山市协和医院185例喉癌激光手术常规病理学检查手术切缘为阴性但术后肿瘤局部复发的24例为复发组,随诊2年无局部复发的161例为无复发组。免疫组化法检测2组手术切缘p53和c-myc蛋白。结果复发组手术切缘中p53蛋白阳性率为66.7%(16/24)明显高于无复发组18.6%(30/161)(P0.05);复发组c-myc蛋白阳性率为83.3%(20/24),无复发组80.1%(129/161)。2组之间差异不显著(P0.05)。结论喉癌手术切缘中p53蛋白阳性与术后局部复发明显相关,可预测喉癌术后局部复发高危患者及指导术后辅助治疗。
[Abstract]:Objective to detect the expression of p53 and c-myc protein in the surgical margin of early laryngeal carcinoma and their relationship with tumor recurrence. Methods 185 cases of laryngeal carcinoma were examined by laser pathology from 2004 to 2010 in Xiehe Hospital of Tangshan City. There were 24 cases of local recurrence of tumor, which were negative but local recurrence after operation. Immunohistochemical method was used to detect p53 and c-myc protein in the surgical margin of the two groups. Results the positive rate of p53 protein in the surgical margin of the recurrent group was 66.7% and 16 / 24 respectively, which was significantly higher than that in the non-recurrence group (18.6R / 161P 0.05), and the c-myc protein in the recurrent group was significantly higher than that in the non-recurrence group. The positive rate of p53 protein was 83.3% and 20 / 24% respectively, and there was no significant difference between the two groups (80.1%) and 12.9% / 161n-2 group (P 0.05). Conclusion the p53 protein expression in the resection margin of laryngeal carcinoma is significantly correlated with the postoperative local recurrence. It can predict the high risk of local recurrence of laryngeal cancer and guide postoperative adjuvant therapy.
【作者单位】：唐山市协和医院病理科;唐山市协和医院耳鼻咽喉头颈外科;
【分类号】：R739.65

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