开角型青光眼中GDxVCC参数和视野指标的相关性研究

发布时间：2018-03-21 07:22

  本文选题：开角型青光眼　切入点：视野　出处：《昆明医学院》2010年硕士论文　论文类型：学位论文

【摘要】： 目的：研究开角型青光眼早、中、晚期GDxVCC和视野的相关性。 方法：利用Humphrey750型计算机自动视野计和德国蔡司公司生产的GDxVCC,对2009年1月～2010年2月到我院就诊的开角型青光眼35人(57眼)及可疑青光眼17人(20眼)进行检查,并根据视野的平均缺损把开角型青光眼患者分为早期组(20眼)、中期组(15眼)和晚期组(22眼)。分析可疑青光眼组、开角型青光眼早、中、晚期组,四组间患者年龄、眼压、屈光度及C/D比值有无差异；比较四个组GDxVCC各参数(TSNIT、SA、IA、TSD、NFI)及视野各指标(MD、PSD、VFI)间有无差异；对各组GDxVCC参数与视野指标进行相关分析。 结果： 1.可疑青光眼、开角型青光眼早、中、晚,四组间年龄、眼压、屈光度差异无统计学意义(P0.05),C/D比值差有统计学意义(P=0.00),经两两比较后开角型青光眼早期及中期有差异。 2.四组间GDxVCC各参数(TSNIT、SA、IA、TSD、NFI)及视野各指标(MD、PSD、VFI)差异均有统计学意义(P=0.00)； 3.可疑青光眼、开角型青光眼早、中、晚期GDxVCC参数与视野指标均呈弱相关性；开角型青光眼各期视野指标与GDxVCC参数的相关性：早期VFI＞MD＞PSD,中期PSD＞MD＞VFI,晚期MD＞VFI＞PSD;开角型青光眼各期GDxVCC参数与视野指标的相关性：早期IA＞SA＞NFI＞TSNIT＞TSD,中期SA＞NFI＞TSNIT＞IA＞TSD,晚期IA＞TSNIT＞NFI＞SA＞TSD。 结论： 1.GDxVCC能够较好测量RNFL厚度； 2.开角型青光眼早期GDxVCC参数与视野指标的相关性较差； 3.开角型青光眼中随着视野缺损程度的加深GDxVCC参数与视野指标的相关系数逐渐增大； 4.开角型青光眼早、中、晚期与视野指标相关性最好的GDxVCC参数不同,分别为IA、SA、IA； 5.开角型青光眼中与GDxVCC参数相关性最好视野指标是MD； 6.在开角型青光眼各期TSNIT及NFI与视野的相关性相对稳定； 7.TSNIT标准差是与视野相关性最差的GDxVCC指标； 8.GDxVCC联合视野能够提高开角型青光眼的早期诊断率；
[Abstract]:Objective: to study the correlation between early, middle and late GDxVCC and visual field in open angle glaucoma. Methods: using Humphrey750 computer automatic visual field meter and GDxVCC produced by Zeiss Company in Germany, 35 patients (57 eyes) with open angle glaucoma and 17 eyes (20 eyes) with suspected glaucoma were examined from January 2009 to February 2010 in our hospital. According to the mean defect of visual field, open angle glaucoma patients were divided into early group (20 eyes) and middle group (15 eyes) and late group (22 eyes). The diopter and the ratio of C / D were different, the differences of GDxVCC parameters and visual field indexes were compared, and the correlation between GDxVCC parameters and visual field index was analyzed. Results:. 1. There was no significant difference in age, intraocular pressure and diopter between the four groups in suspected glaucoma, early, middle and late open angle glaucoma. There was no significant difference in the ratio of P 0.05 / C / D between the four groups. There were significant differences in the early and middle stages of open angle glaucoma after pairwise comparison. 2. There were significant differences in the GDxVCC parameters (TSNITT) and the visual field (GDxVCC) between the four groups. 3. There was a weak correlation between the parameters of GDxVCC and visual field in the early, middle and late stage of open angle glaucoma. The correlation between the visual field parameters of open angle glaucoma and GDxVCC parameters was as follows: early VFI > MD > PSD, middle stage PSD > MD > VFI, late stage MD > VFI > PSD, and early stage IA > SA > NFI > TSNIT > TSD, middle stage > NFI > TSNIT > IA > TSD, late stage IA > TSNIT > NFI > SA > TSD > TSD. Conclusion:. 1.GDxVCC can better measure the thickness of RNFL; 2. The correlation between GDxVCC parameters and visual field index was poor in the early stage of open-angle glaucoma. 3. In open-angle glaucoma, the correlation coefficient between GDxVCC parameter and visual field index gradually increased with the deepening of visual field defect. 4. The GDxVCC parameters with the best correlation with visual field index were different in early, middle and late stage of open-angle glaucoma. 5. In open-angle glaucoma, MDD is the best visual field index correlated with GDxVCC parameters. 6. The correlation between TSNIT and NFI and visual field was relatively stable in each stage of open-angle glaucoma. 7.TSNIT standard deviation is the worst correlation with visual field GDxVCC index; 8. GDxVCC combined visual field can improve the early diagnosis rate of open-angle glaucoma.
【学位授予单位】：昆明医学院
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R775.1

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