紫杉醇在青光眼滤过术后的抗增殖作用

发布时间：2018-03-23 14:15

本文选题：青光眼　切入点：小梁切除术　出处：《眼科新进展》2015年11期

【摘要】：目的探讨紫杉醇对青光眼滤过术后的抗增殖作用。方法选取山东省菏泽市立医院眼科2010年1月至2014年6月收治的原发性闭角型青光眼患者96例(104眼),随机分为4组:A组术中给予0.20 g·L-1丝裂霉素C,B、C、D组术中分别给予0.03 g·L-1、0.05 g·L-1、0.10 g·L-1紫杉醇。所有患者均行标准的小梁切除术,术后均随访6个月,对患者术后1周、1个月、3个月、6个月的视力、眼压、滤过泡、并发症等情况进行观察记录。结果 4组患者术前视力组间差异无统计学意义(均为P0.05),术后不同时间组间差异均无统计学意义(均为P0.05),术后与术前比较,差异也均无统计学意义(均为P0.05)。术后1周、1个月、3个月与6个月,4组患者的功能性滤过泡比率差异均无统计学意义(χ2=0.000、0.739、1.031、1.083,均为P0.05)。4组患者的术前眼压、术后1周眼压差异均无统计学意义(均为P0.05),术后1个月、3个月、6个月A组与D组间眼压差异均无统计学意义(均为P0.05),D组与B组、C组差异均有统计学意义(均为P0.05)。术后A组有2眼结膜伤口有轻度渗漏,4眼发生浅前房,其余3组均未出现以上情况。结论紫杉醇用于青光眼滤过术能有效降低眼压,维持滤过泡功能,且副作用较小。
[Abstract]:Objective to investigate the antiproliferative effect of paclitaxel on glaucoma filtering. Methods 96 patients with primary angle-closure glaucoma treated in Heze City Hospital of Shandong Province from January 2010 to June 2014 were randomly divided into 4 groups. Group A was given 0. 20 g L-1 mitomycin during operation and group D was given 0. 03 g L -1 0. 05 g L -1 and 0. 10 g L -1 paclitaxel respectively. All patients were treated with standard trabeculectomy. All the patients were followed up for 6 months. The visual acuity, intraocular pressure, filtering bleb were 1 week, 1 month, 3 months and 6 months after operation. Results there was no significant difference in preoperative visual acuity between the four groups (P 0.05), but there was no significant difference between groups at different time after operation (all P 0.05). There was no significant difference in the functional filtration bleb ratio between the 4 groups (蠂 2 0.0000.7391.031 卤1.083, P 0.05). The preoperative intraocular pressure of the patients in the P0.05 group was higher than that in the control group (P 0.05), and there was no significant difference in the functional filtration bleb ratio between the 4 groups (蠂 2 0.000 0. 739 1. 031 卤1 083) after 1 week, 1 month, 3 months and 6 months postoperatively. There was no significant difference in IOP between group A and group D at 1 month, 3 months and 6 months after operation (P 0.05). In group A, there were 2 eyes with slight leakage of conjunctiva wound and 4 eyes with shallow anterior chamber. Conclusion Paclitaxel can effectively reduce intraocular pressure and maintain filtering bleb function with less side effects.
【作者单位】：菏泽市立医院眼科;
【分类号】：R779.6

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