0.2%酒石酸溴莫尼定联合0.25%倍他洛尔的短期降眼压疗效及安全性研究

发布时间：2018-03-27 16:29

本文选题：青光眼/药物治疗　切入点：眼压　出处：《眼科》2015年03期

【摘要】：目的观察0.2%酒石酸溴莫尼定滴眼液联合应用0.25%倍他洛尔混悬液对原发性开角型青光眼及高眼压症患者3个月的降眼压疗效及安全性。设计前瞻性病例系列。研究对象原发性开角型青光眼32例(57眼),高眼压症14例(27眼)。方法给予0.2%酒石酸溴莫尼定滴眼液及0.25%倍他洛尔混悬液早晚各2次点眼,分别于用药后2、4、8、12周复查,观察用药前后的眼压及不良反应,共观察3个月。主要指标眼压、不良反应。结果用药后2~12周眼压平均降低5.71~7.38mm Hg,平均降幅为21.94%~39.01%;左右眼间降眼压效果无明显区别(P0.05);男女性别之间降眼压效果亦无显著差异(P0.05)。随访期间,3例患者出现不能耐受的眼部刺激症状而退出试验。7例(8.33%)出现眼分泌物增多;5例(5.95%)出现眼部刺痛;10例(11.9%)出现眼部烧灼感;7例出现口苦(8.33%);3例(3.57%)出现眉弓胀痛伴头痛;视力及前节无显著变化。结论本文的短期研究显示,0.2%酒石酸溴莫尼定滴眼液联合0.25%倍他洛尔混悬液对原发性开角型青光眼及高眼压症患者具有较好的降眼压效果,副作用少。
[Abstract]:Objective to observe the efficacy and safety of 0.2% bromonidine tartrate eye drops combined with 0.25% betalool suspension in lowering intraocular pressure in patients with primary open-angle glaucoma and hyperbaric hypertension for 3 months. Participants 32 patients with primary open-angle glaucoma (32 eyes) and 27 eyes with high intraocular pressure (IOP) were treated with 0.2% bromonidine tartrate eye drops and 0.25% betaloprolol suspension twice in the morning and evening. The intraocular pressure (IOP) and adverse reactions were observed at 812 weeks after treatment for 3 months. The main indexes of IOP were intraocular pressure (IOP), intraocular pressure (IOP), and intraocular pressure (IOP). Results the intraocular pressure (IOP) decreased by 21.94% (39.01%) at 12 weeks after treatment, there was no significant difference in the effect of IOP reduction between right and left eyes (P0.05), and there was no significant difference in the effect of IOP reduction between male and female (P 0.05). No significant difference was found in 3 patients with IOP during the follow-up period. Eye irritation symptoms were tolerated in 7 cases (8.33) and eye secretion increased in 5 cases (5.95%) eye prickly pain was found in 10 cases (11.9%) eye burning sensation was found in 7 cases (8. 33%) and there were 3 cases (3.57) with bilge of eyebrow arch and headache. Conclusion the short-term study shows that the combination of 0.2% bromonidine tartrate eye drops and 0.25% betalool suspension has a good effect on lowering IOP in patients with primary open-angle glaucoma and high intraocular pressure with less side effects.
【作者单位】：首都医科大学附属北京同仁医院北京同仁眼科中心眼科学与视觉科学北京市重点实验室;
【基金】：首都临床特色应用研究(Z121107001012046)
【分类号】：R775

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